Resveratrol and Health: The Starting Point
Resveratrol and Health: The Starting Point
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DOI：
10.1002/cbic.201200193
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发表时间：
2012-06-18
期刊：
影响因子：
3.2
通讯作者：
Zoratti, Mario
中科院分区：
文献类型：
--
作者：
Biasutto, Lucia;Mattarei, Andrea;Zoratti, Mario
青春的瀑布？白藜芦醇，红葡萄酒中著名的植物抗毒素，已知间接激活AMPK，但这是如何发生的尚不清楚。在最近发表在Cell，S. J. Park，JH Chung及其同事确定了信号级联，其开始于磷酸二酯酶的抑制，特别是PDE 4。但问题仍然存在，即使新的视角打开。
Cascade of youth? Resveratrol, the celebrated phytoalexin of red wine, was known to activate AMPK indirectly, but how this happened was unclear. In a paper recently published in Cell, S.-J. Park, JH Chung and co-workers identify the signalling cascade, which begins with the inhibition of phosphodiesterases, in particular PDE4. But questions remain, even while new perspectives open up.