Nanoindentation of the insertional zones of human meniscal attachments into underlying bone
Nanoindentation of the insertional zones of human meniscal attachments into underlying bone
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DOI：
10.1016/j.jmbbm.2008.10.005
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发表时间：
2009-08-01
影响因子：
3.9
通讯作者：
Donahue, T. L. Haut
中科院分区：
文献类型：
--
作者：
Hauch, K. N.;Oyen, M. L.;Donahue, T. L. Haut
纤维软骨膝关节位于股骨髁和胫骨平台之间，主要通过前角和后角的四个附件锚定在胫骨上。股骨附件与胫骨平台的牢固固定提供了对股骨主体挤压力的抵抗力，使股骨附件有助于将载荷从股骨传递到胫骨。临床上，髋臼附件和插入骨的撕裂和破裂是罕见的。虽然已经提出，半月板置换的成功取决于几个因素，其中之一是置换物与胫骨平台的牢固固定和牢固连接，但对半月板附件的材料特性以及从半月板到软骨下骨的材料特性过渡知之甚少。本研究的目的是使用纳米压痕法研究通过未钙化和钙化的纤维软骨从骨附着到底层软骨下骨的过渡。对前、后牙弓止点进行纳米压痕测试，测量瞬时弹性模量和无限时间弹性模量。从外韧带到软骨下骨的弹性模量呈双线性增加。在相似的压痕位置，前附件的弹性模量始终大于匹配的后附件。这些结果表明，从靠近韧带附着点的插入浅区到骨的较深区存在刚度梯度。这些信息将有助于成功的胫骨置换的继续发展和对胫骨平台置换固定的理解。(C)2008爱思唯尔有限公司保留所有权利。
The fibrocartilagenous knee menisci are situated between the femoral condyles and tibia plateau and are primarily anchored to the tibia by means of four attachments at the anterior and posterior horns. Strong fixation of meniscal attachments to the tibial plateau provide resistance to extruding forces of the meniscal body, allowing the menisci to assist in load transmission from the femur to the tibia. Clinically, tears and ruptures of the meniscal attachments and insertion to bone are rare. While it has been suggested that the success of a meniscal replacement is dependent on several factors, one of which is the secure fixation and firm attachment of the replacement to the tibial plateau, little is known about the material properties of meniscal attachments and the transition in material properties from the meniscus to subchondral bone. The objective of this study was to use nanoindentation to investigate the transition from meniscal attachment into underlying subchondral bone through uncalcified and calcified fibrocartilage. Nanoindentation tests were performed on both the anterior and posterior meniscal insertions to measure the instantaneous elastic modulus and elastic modulus at infinite time. The elastic moduli were found to increase in a bi-linear fashion from the external ligamentous attachment to the subchondral bone. The elastic moduli for the anterior attachments were consistently larger than those for the matching posterior attachments at similar indentation locations. These results show that there is a gradient of stiffness from the superficial zones of the insertion close to the ligamentous attachment into the deeper zones of the bone. This information will be useful in the continued development of successful meniscal replacements and understanding of fixation of the replacements to the tibial plateau. (C) 2008 Elsevier Ltd. All rights reserved.