The Prevalence and Findings of Subclinical Influenza-associated Cardiac Abnormalities among Japanese Patients.
The Prevalence and Findings of Subclinical Influenza-associated Cardiac Abnormalities among Japanese Patients.
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DOI：
10.2169/internalmedicine.0316-17
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发表时间：
2018-07-01
期刊：
影响因子：
--
通讯作者：
Ishizaka N
中科院分区：
文献类型：
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作者：
Ito T;Akamatsu K;Ukimura A;Fujisaka T;Ozeki M;Kanzaki Y;Ishizaka N
虽然流感感染中危及生命的心脏并发症很少见，但与亚临床流感相关的心脏异常可能更频繁发生。我们调查了亚临床心脏表现的患病率。在获得受试者的书面知情同意后，102名受试者被纳入本研究。研究对象接受了第一组检查，包括心电图（ECG）、超声心动图和心脏酶水平的测量。在这些检查中有一项或多项异常发现的患者被鼓励在2周后进行重复检查。在纳入的102名受试者中，22名（21.6%）被判断有心脏表现，包括ST-T异常、心包积液、舒张功能障碍和心酶升高。这20名受试者中有18人在14天后进行了第二次筛查，发现其中11人在第二次检查中没有心脏发现。这表明这种异常只是暂时的，因此可能与流感有关。大约20%的流感患者有心脏方面的发现，包括ST-T段异常、心包积液和心脏酶升高。在102例被研究的患者中，心脏症状仅为轻微和短暂性；然而，医生应该注意流感感染相关的心脏异常，因为这种异常可能并不罕见。
Although life-threatening cardiac complications in influenza infection are rare, subclinical influenza-associated cardiac abnormalities may occur more frequently. We investigated the prevalence of subclinical cardiac findings. After obtaining their written informed consent, 102 subjects were enrolled in the present study. The study subjects underwent a first set of examinations, which included electrocardiography (ECG), echocardiography, and the measurement of their cardiac enzyme levels. Those with one or more abnormal findings among these examinations were encouraged to undergo a repeat examination 2 weeks later. Among the 102 subjects enrolled, 22 (21.6%) were judged to have cardiac findings, including ST-T abnormalities, pericardial effusion, diastolic dysfunction, and cardiac enzyme elevation. Eighteen of these 20 subjects underwent a second screening at a median of 14 days later, and it was found that 11 of the 18 subjects were free from cardiac findings on this second examination. This suggested that the abnormalities were only transient and they therefore might have been associated with influenza. Approximately 20% of the influenza patients enrolled had cardiac findings, including ST-T segment abnormalities, pericardial effusion, and cardiac enzyme elevation. Among the 102 patients who were studied, the cardiac findings were only mild and transient; however, physicians should be aware of influenza infection-associated cardiac abnormalities because such abnormalities may not be rare.