Highly sensitive amyloid detection enabled by thioflavin T dimers
Highly sensitive amyloid detection enabled by thioflavin T dimers
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DOI：
10.1039/c005255h
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发表时间：
2010-01-01
影响因子：
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通讯作者：
Gao, Jianmin
中科院分区：
文献类型：
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作者：
Qin, Luoheng;Vastl, Julian;Gao, Jianmin
特异性靶向淀粉样蛋白结构的荧光分子对于淀粉样蛋白研究是高度期望的。在此，我们显示了硫磺素T的二聚体设计将其与Ab淀粉样蛋白的结合亲和力提高了高达70倍，同时不牺牲淀粉样蛋白结合时的特异性和“点亮”特征。
Fluorescent molecules that specifically target amyloid structures are highly desirable for amyloid research. Herein, we show a dimeric design of thioflavin T improves its binding affinity to Ab amyloid by up to 70 fold, while not sacrificing the specificity and the "light-up" feature upon amyloid binding.