Changes in Rat 50-kHz Ultrasonic Vocalizations During Dopamine Denervation and Aging: Relevance to Neurodegeneration.
Changes in Rat 50-kHz Ultrasonic Vocalizations During Dopamine Denervation and Aging: Relevance to Neurodegeneration.
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DOI：
10.2174/1570159x1302150525122416
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发表时间：
2015
影响因子：
5.3
通讯作者：
Ciucci MR
中科院分区：
文献类型：
--
作者：
Johnson AM;Grant LM;Schallert T;Ciucci MR
声音交流受到神经退行性疾病（如帕金森病）和衰老的负面影响。帕金森病和衰老中语音缺陷的神经和感觉运动机制尚未得到很好的理解。大鼠超声发声为研究这些条件下的沟通缺陷和这些缺陷的机制提供了一个独特的行为模型。本综述的目的是检查现有文献的方法，使用大鼠超声发声与帕金森病，多巴胺去神经支配和衰老的原发性疾病病理学。虽然只有少量的论文被发现为每个这些主题，结果表明，共享和独特的声学缺陷在超声发声存在跨条件，这些声学缺陷是由于多巴胺信号或去神经支配的变化和老化模型的变化，疑核，在神经肌肉接头的水平，和组成的声带在喉。我们的结论是，超声发声是一个有用的工具，用于研究生物学机制的基础上声乐通信缺陷的神经退行性疾病和老化。
Vocal communication is negatively affected by neurodegenerative diseases, such as Parkinson disease, and by aging. The neurological and sensorimotor mechanisms underlying voice deficits in Parkinson disease and aging are not well-understood. Rat ultrasonic vocalizations provide a unique behavioral model for studying communication deficits and the mechanisms underlying these deficits in these conditions. The purpose of this review was to examine the existing literature for methods using rat ultrasonic vocalization with regard to the primary disease pathology of Parkinson disease, dopamine denervation, and aging. Although only a small amount of papers were found for each of these topics, results suggest that both shared and unique acoustic deficits in ultrasonic vocalizations exist across conditions and that these acoustic deficits are due to changes in either dopamine signaling or denervation and in aging models changes to the nucleus ambiguus, at the level of the neuromuscular junction, and the composition of the vocal folds in the larynx. We conclude that ultrasonic vocalizations are a useful tool for studying biologic mechanisms underlying vocal communication deficits in neurodegenerative diseases and aging.