Role of nuclear receptor corepressors in leukemogenesis.
Role of nuclear receptor corepressors in leukemogenesis.
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核受体辅阻遏物在白血病发生中的作用。
DOI：
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发表时间：
2001
影响因子：
--
通讯作者：
A. Zelent
中科院分区：
文献类型：
--
作者：
F. Guidez;A. Zelent
在过去的二十年中，已经采取了重要步骤，以了解许多恶性疾病的分子发病机制。癌症遗传学的研究已经确定了在细胞增殖和分化的调节中起核心作用的基因座，并且其突变与肿瘤发生相关。这些基因座的功能特征往往表明，它们编码的因子，这是直接参与基因表达的转录调控。在过去的二十年里，癌症的治疗也取得了一些显著的进展，特别是造血系统恶性肿瘤，其中急性早幼粒细胞白血病（APL）在治疗创新和理解疾病过程中的分子事件方面都处于领先地位。APL可以响应于全反式维甲酸（ATRA）作为唯一治疗剂的分化治疗的证明使得这种相对罕见的造血系统恶性肿瘤成为模型疾病。核受体（NR）超家族成员视黄酸受体-α（RARα）基因座被易位到一个功能未知的基因PML（早幼粒细胞白血病），导致PML-RAR α和RAR α-PML融合蛋白的表达，这一发现进一步增强了人们对APL的兴趣。本文将回顾目前的认识的作用，NR辅抑制剂在APL的分子发病机制中发挥作用，并解决最近的数据直接牵连这些分子的过程中与更常见的骨髓和淋巴恶性肿瘤的发展。
In the past two decades important steps have been taken towards the understanding of the molecular pathogeneses that underlie many malignant diseases. Studies in cancer genetics have identified loci which play central roles in the regulation of cell proliferation and differentiation and whose mutations are associated with tumorigenesis. Functional characterizations of these loci often demonstrated that they encode factors, which are directly involved in transcriptional regulation of gene expression. The last two decades have also seen some remarkable advances in the treatment of cancer, particularly hematopoietic malignancies, where acute promyelocytic leukemia (APL) has led the way both in treatment innovation and in the understanding of the molecular events underlying the disease process. The demonstration that APL could respond to differentiation therapy with all-transretinoic acid (ATRA) as a sole therapeutic agent has made this relatively rare hematopoietic malignancy a model disease. Interest in APL was further enhanced by the discovery that the retinoic acid receptor-α (RARα) locus, a member of the nuclear receptor (NR) superfamily, was reciprocally translocated to a gene of unknown function called PML (for Promyelocytic Leukemia) leading to expression of PML-RARa and RARa-PML fusion proteins. This article will review the current understanding of the role that the NR corepressors play in the molecular pathogenesis of APL and address recent data directly implicating these molecules in processes associated with the development of more common myeloid and lymphoid malignancies.
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影响因子：
10.5
作者：
Chen, GQ;Fernandez, J;Courey, AJ
通讯作者：
Courey, AJ
DOI：
10.1073/pnas.93.15.7900
发表时间：
1996-07-23
影响因子：
11.1
作者：
Early, E;Moore, MAS;Dmitrovsky, E
通讯作者：
Dmitrovsky, E
影响因子：
56.9
作者：
Zhugang Wang;L. Delva;M. Gaboli;R. Rivi;M. Giorgio;C. Cordon-Cardo;F. Grosveld;P. Pandolfi
通讯作者：
Zhugang Wang;L. Delva;M. Gaboli;R. Rivi;M. Giorgio;C. Cordon-Cardo;F. Grosveld;P. Pandolfi
DOI：
10.1073/pnas.92.6.2249
发表时间：
1995-03-14
影响因子：
11.1
作者：
COOK, M;GOULD, A;ZELENT, A
通讯作者：
ZELENT, A
影响因子：
56.9
作者：
Look, AT
通讯作者：
Look, AT