Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men
Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men
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DOI：
10.1038/sj.ijo.0803539
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发表时间：
2007-04-01
影响因子：
4.9
通讯作者：
Di Marzo, V.
中科院分区：
文献类型：
--
作者：
Cote, M.;Matias, I.;Di Marzo, V.
目的：过度腹内肥胖（IAA）和导致2型糖尿病和心血管疾病的代谢并发症之间的联系是众所周知的。阻断大麻素CB 1受体的内源性大麻素作用可减少这些并发症。在这里，我们调查了IAA、循环内源性大麻素水平和男性肥胖受试者心脏代谢风险标志物之间的关系。设计、受试者和测量：内源性大麻素、大麻素酰胺（AEA）和2-花生四烯酰甘油（2-AG）的空腹血浆水平，在62名未经治疗的无症状男性体重指数（BMI）研究样本中，结果：血浆2-AG水平与BMI、腰围、CT测量的IAA、空腹血浆甘油三酯和胰岛素水平呈正相关，与高密度脂蛋白胆固醇和脂联素水平呈负相关，而与AEA无相关性。BMI值相似（>= 30 kg/m2）但IAA量显著不同（< vs >= 130 cm（2），n = 17）的肥胖男性在高IAA存在下表现出更高的2-AG水平。肥胖男性与低水平的IAA与nonobese controls.Conclusions：这些结果提供了证据，在男性之间的关系的关键内源性大麻素，2-AG，和心脏代谢的危险因素，包括IAA之间没有差异2-AG浓度。
Objective: The link between excess intra-abdominal adiposity (IAA) and metabolic complications leading to type 2 diabetes and cardiovascular disease is well recognized. Blockade of endocannabinoid action at cannabinoid CB1 receptors was shown to reduce these complications. Here, we investigated the relationship between IAA, circulating endocannabinoid levels and markers of cardiometabolic risk in male obese subjects.Design, subjects and measurements: Fasting plasma levels of the endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), were measured by liquid chromatography-mass spectrometry in a study sample of 62 untreated asymptomatic men with body mass index (BMI) from 18.7 to 35.2 kg/m(2).Results: Plasma 2-AG, but not AEA, levels correlated positively with BMI, waist girth, IAA measured by computed tomography, and fasting plasma triglyceride and insulin levels, and negatively with high-density lipoprotein cholesterol and adiponectin levels. Obese men with similar BMI values (>= 30 kg/m2) but who markedly differed in their amount of IAA (< vs >= 130cm(2), n = 17) exhibited higher 2-AG levels in the presence of high IAA. No difference in 2-AG concentrations was observed between obese men with low levels of IAA vs nonobese controls.Conclusions: These results provide evidence for a relationship in men between a key endocannabinoid, 2-AG, and cardiometabolic risk factors, including IAA.