Adult height and the risks of cardiovascular disease and major causes of death in the Asia-Pacific region: 21 000 deaths in 510 000 men and women
Adult height and the risks of cardiovascular disease and major causes of death in the Asia-Pacific region: 21 000 deaths in 510 000 men and women
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DOI：
10.1093/ije/dyp150
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发表时间：
2009-08-01
影响因子：
7.7
通讯作者：
Huxley, Rachel R.
中科院分区：
文献类型：
--
作者：
Lee, Crystal Man Ying;Barzi, Federica;Huxley, Rachel R.
方法 纳入来自亚太队列研究合作数据库的 39 项研究。我们使用 Cox 比例风险回归模型来估计身高和预先指定的结果之间的关联。结果 总共包括 510 800 名参与者，其中 21 623 人死亡。在男性中，身高与冠心病 (CHD)、中风、CVD、损伤和总死亡率之间存在负线性相关关系。身高增加 1-SD (6 cm) 的风险比 [95 置信区间 (CI)] 范围从受伤的 0.85 (0.800.91) 到总死亡率的 0.97 (0.950.98)。女性身高与冠心病、出血性中风和心血管疾病之间也存在类似的趋势。身高与癌症死亡率之间观察到呈正线性相关。身高每增加一个标准差，男性和女性患癌症的风险分别增加 5 (28) 和 9 (514)。亚洲和澳大利亚队列之间没有观察到区域差异。调整教育标志并没有改变结果。 结论 身高与心血管疾病和癌症的相反关系表明，在制定儿童营养国家政策时需要小心，以免对主要非传染性疾病的发病率产生意想不到的后果。
Methods Thirty-nine studies from the Asia Pacific Cohort Studies Collaboration database were included. We used Cox proportional hazard regression models to estimate the associations between height and pre-specified outcomes.Results A total of 510 800 participants with 21 623 deaths were included. Amongst men, inverse linear associations were observed between height and coronary heart disease (CHD), stroke, CVD, injury and total mortality. The hazard ratios [95 confidence intervals, (CI)] for a 1-SD ( 6 cm) increment in height ranged from 0.85 (0.800.91) for injury to 0.97 (0.950.98) for total mortality. Similar trends were found between height and CHD, haemorrhagic stroke and CVD in women. A positive linear association was observed between height and cancer mortality. For each standard deviation greater height, the risk of cancer was increased by 5 (28) and 9 (514) in men and women, respectively. No regional difference was observed between Asian and Australasian cohorts. Adjusting for markers of education did not alter the results.Conclusions The opposing relationships of height with CVD and cancer suggest that care is required in setting national policies on childhood nutrition lest they have unintended consequences on the incidence of major non-communicable diseases.