A Small Arterial substitute: Expanded Microporous Polytetrafluoroethylene. Patency Versus Porosity
A Small Arterial substitute: Expanded Microporous Polytetrafluoroethylene. Patency Versus Porosity
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小动脉替代品：膨胀微孔聚四氟乙烯。
DOI：
10.1097/00000658-197508000-00010
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发表时间：
1975
影响因子：
9
通讯作者：
R. Roe
中科院分区：
文献类型：
--
作者：
C. Campbell;D. Goldfarb;R. Roe
将89个直径为4 mm的微孔聚四氟乙烯（PTFE）移植物置于犬的颈动脉和股动脉中。从术后3天开始，以不同的间隔处死动物。术后10个月，4只动物仍存活，移植物通畅。89个移植物中有24个闭塞，总体通畅率为73%。移植物材料的原纤维长度（孔径）在4 - 110微米之间变化。平均孔径范围为9至65微米。壁厚为0.3 ~ 0.75 mm，密度为0.24 ~ 0.35 g/ml。观察组织长入、新生内膜化和通畅率，并与扩张型PTFE的孔径、壁厚和密度进行比较。孔径是组织长入、新生内膜化和通畅性的主要决定因素。在平均孔径为22微米或更小的51个移植物中，有6个闭塞，通畅率为88%。有38个移植物的平均孔径为34微米或更大。在这38例移植物中，观察到18例闭塞，通畅率为53%。通畅的移植物显示组织向内生长，毛细血管形成和薄的新生内膜。使用小孔移植物，预期犬的通畅率为90%。膨胀微孔PTFE具有易于处理、强度和柔韧性，可能是人体血管假体的首选。
Eighty-nine grafts of expanded microporous polytetrafluoroethylene (PTFE) with a diameter of 4 mm, were placed in the carotid and femoral arteries of dogs. The animals were sacrificed at varying intervals beginning three days after operation. Four animals remain alive with patent grafts 10 months post-operatively. Twenty-four of 89 grafts were occluded, an overall patency of 73%. Fibril length (pore size) of the graft material was varied from 4 to 110 microns. Average pore size ranged from 9 to 65 microns. Wall thickness varied from 0.3 to 0.75 mm. Density ranged from 0.24 to 0.35 g/ml. Tissue ingrowth, neointimization and patency rate as compared to pore size, wall-thickness and density of expanded PTFE were observed. Pore size is the primary determinant of tissue ingrowth, neointimization and patency. Of 51 grafts with an average pore size of 22 microns or less, there were 6 occlusions, an 88% patency rate. There were 38 grafts with an average pore size of 34 microns or greater. In these 38 grafts, 18 occlusions were observed, a 53% patency rate. Patent grafts demonstrated tissue ingrowth, capillary formation an a thin neointima. Using small pore grafts, patency rates of 90% can be anticipated in the dog. Expanded microporous PTFE with its ease of handling, strength and pliability may be the vascular prosthesis of choice in man.