Carotid Body Chemoreceptor Function Is Impaired by Vecuronium during Hypoxia
Carotid Body Chemoreceptor Function Is Impaired by Vecuronium during Hypoxia
复制标题
缺氧期间维库溴铵损害颈动脉体化学感受器功能
DOI：
10.1097/00000542-199812000-00025
复制
发表时间：
1998
期刊：
影响因子：
8.8
通讯作者：
L. Eriksson
中科院分区：
文献类型：
--
作者：
N. Wyon;H. Joensen;Yuji Yamamoto;S. Lindahl;L. Eriksson
背景神经肌肉阻滞剂降低部分神经肌肉阻滞时人体对低氧的呼吸反应。推测维库溴铵在低氧状态下可损害颈动脉小体化学感受器功能。方法在7只机械通气新西兰大白兔连续硫喷妥钠麻醉下，观察全身应用维库溴铵对颈动脉窦神经单个神经纤维记录的缺氧时单个化学感受器活动的影响。在常压通气法中，在4个氧合水平下测定单个颈动脉小体化学感受器的低氧化学敏感性；这些测定在注射前、静脉注射维库溴铵0.1 mg和0.5 mg后、然后在90分钟的恢复期内重复3次。化学感受器对低氧的敏感性符合双曲线方程：化学感受器输出量(Hz)=a+bxPaO(2)-1(Mm Hg)。结果与对照组相比，静脉注射维库溴铵0.1 mg和0.5 mg后化疗敏感性降低，缺氧反应曲线明显降低(P<；0.05)。值得注意的是，维库溴铵的作用存在差异；一些化学感受器制剂仅表现出轻微的损害，而一些制剂对低氧几乎没有反应。维库溴铵0.5 mg后30min和60min化疗敏感性明显降低，90min后自行恢复。结论维库溴铵在低氧状态下对颈动脉小体化学感受器功能有不同程度的抑制作用，这种抑制作用可自行恢复。
Background Neuromuscular blocking agents reduce the human ventilatory response to hypoxia at partial neuromuscular block. It was hypothesized that vecuronium impairs carotid body chemoreceptor function during hypoxia. Method The effect of systemic administration of vecuronium on single chemoreceptor activity during hypoxia, as recorded from a single nerve fiber preparation of the carotid sinus nerve, was studied in seven mechanically ventilated New Zealand White rabbits during continuous thiopental anesthesia. During normoventilation, the isocapnic hypoxic chemosensitivity of the single carotid body chemoreceptor was measured at four levels of oxygenation; these measurements were repeated at six separate occasions: control recording before injection, after intravenous administrations of 0.1 mg and 0.5 mg of vecuronium, and then at three occasions during a 90‐min recovery period. Chemoreceptor chemosensitivity during isocapnic hypoxia was expressed as a hyperbolic function: Chemoreceptor output (Hz) = a + b x PaO(2)‐1 (mmHg). Results Chemosensitivity was reduced after both 0.1 mg and 0.5 mg vecuronium intravenous administration compared with control measurements; the hypoxic response curve was significantly depressed after both doses (P < 0.05). Notably, there was variation in the effect of vecuronium; some chemoreceptor preparations showed only minimal impairment, whereas some showed an almost abolished response to hypoxia. The chemosensitivity remained significantly depressed at 30 and 60 min but had recovered spontaneously at 90 min after 0.5 mg vecuronium. Discussion It is concluded that vecuronium depresses carotid body chemoreceptor function to a varying extent during hypoxia and that the depression recovers spontaneously.