Developmental Changes in Brain Network Hub Connectivity in Late Adolescence
Developmental Changes in Brain Network Hub Connectivity in Late Adolescence
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DOI：
10.1523/jneurosci.5043-14.2015
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发表时间：
2015-06-17
影响因子：
5.3
通讯作者：
Fornito, Alex
中科院分区：
文献类型：
--
作者：
Baker, Simon T. E.;Lubman, Dan I.;Fornito, Alex
人类的大脑在整个青春期和成年早期都经历了实质性的发展。这一成熟的过程被认为包括精细化大脑假定的连接中枢区域之间的连接，这些区域共同形成一个密集的核心，增强解剖上分布的和功能上专门的神经系统的功能整合。在这里，我们使用纵向扩散磁共振成像来表征31名15至19岁的青少年在两年时间里80个皮质和皮质下解剖区域之间的连通性的变化。全连接组分析表明，在研究期间，只有一小部分连接显示出统计上显著的发育变化，分别有8%和6%的连接表现出结构连接性的减少和增加。尽管如此，这些连接分别连接了80个区域中的93%和90%，表明了一种选择性的、但在解剖学上分布的发育变化模式，涉及大脑的大部分。枢纽地区表现出明显的相互高度联系的趋势，表明了强大的“富豪俱乐部”组织。此外，中枢之间的连通性不成比例地受到发展的影响，以至于皮质下中枢之间的连通性随着时间的推移而下降，而额叶-皮质下和额叶-顶叶-中枢的连通性随着时间的推移而增加。这些发现表明，青春期后期的特点是中枢-中枢连接性的选择性但显著的重塑，中枢的拓扑组织将重点从皮质下中枢转移到额叶中枢区域，其作用越来越突出。
The human brain undergoes substantial development throughout adolescence and into early adulthood. This maturational process is thought to include the refinement of connectivity between putative connectivity hub regions of the brain, which collectively form a dense core that enhances the functional integration of anatomically distributed, and functionally specialized, neural systems. Here, we used longitudinal diffusion magnetic resonance imaging to characterize changes in connectivity between 80 cortical and subcortical anatomical regions over a 2 year period in 31 adolescents between the ages of 15 and 19 years. Connectome- wide analysis indicated that only a small subset of connections showed evidence of statistically significant developmental change over the study period, with 8% and 6% of connections demonstrating decreased and increased structural connectivity, respectively. Nonetheless, these connections linked 93% and 90% of the 80 regions, respectively, pointing to a selective, yet anatomically distributed pattern of developmental changes that involves most of the brain. Hub regions showed a distinct tendency to be highly connected to each other, indicating robust "rich-club" organization. Moreover, connectivity between hubs was disproportionately influenced by development, such that connectivity between subcortical hubs decreased over time, whereas frontal-subcortical and frontal-parietal hub-hub connectivity increased over time. These findings suggest that late adolescence is characterized by selective, yet significant remodeling of hub-hub connectivity, with the topological organization of hubs shifting emphasis from subcortical hubs in favor of an increasingly prominent role for frontal hub regions.