Lifespan extension and delay of age-related functional decline caused by Rhodiola rosea depends on dietary macronutrient balance.
Lifespan extension and delay of age-related functional decline caused by Rhodiola rosea depends on dietary macronutrient balance.
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DOI：
10.1186/2046-2395-2-5
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发表时间：
2013-04-02
期刊：
影响因子：
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通讯作者：
Lushchak OV
中科院分区：
文献类型：
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作者：
Gospodaryov DV;Yurkevych IS;Jafari M;Lushchak VI;Lushchak OV
本研究旨在评价乌克兰西部传统药用植物红景天根茎粉对果蝇寿命和与年龄相关的生理功能的影响。摄食5.0 mg/ml和10.0 mg/ml玫瑰根茎粉的苍蝇，中位寿命延长14%~17%，而30.0 mg/ml时，苍蝇寿命下降9%~12%。该制剂不会降低果蝇的繁殖力。补充玫瑰花对寿命的影响与饲料组成有关。寿命延长15%至21%仅在蛋白质与碳水化合物比例小于1的饮食中观察到。寿命延长还取决于大量营养素的总浓度。因此，对于含有15%酵母和15%蔗糖的饲料，寿命没有延长，而对于蛋白质与碳水化合物比例为20：1的饲料，玫瑰红葡萄酒的寿命减少了约10%。与对照组相比，喂食红景天制剂的果蝇身体更活跃，对氧化还原循环化合物甲萘二酮不那么敏感，热昏迷开始的时间更长。红景天对抗逆性和运动能力的正面效应在中年时最高。目前的数据表明，长期补充玫瑰根茎不仅可以延长黑腹牡蛎的寿命，还可以延缓与年龄相关的体力活动的下降，并提高抗逆性，这取决于饮食中的蛋白质与碳水化合物的比例。
This study was conducted to evaluate the effects of rhizome powder from the herb Rhodiola rosea, a traditional Western Ukraine medicinal adaptogen, on lifespan and age-related physiological functions of the fruit fly Drosophila melanogaster. Flies fed food supplemented with 5.0 mg/ml and 10.0 mg/ml of R. rosea rhizome powder had a 14% to 17% higher median lifespan, whereas at 30.0 mg/ml lifespan was decreased by 9% to 12%. The preparation did not decrease fly fecundity. The effect of R. rosea supplement on lifespan was dependent on diet composition. Lifespan extension by 15% to 21% was observed only for diets with protein-to-carbohydrate ratios less than 1. Lifespan extension was also dependent on total concentration of macronutrients. Thus, for the diet with 15% yeast and 15% sucrose there was no lifespan extension, while for the diet with protein-to-carbohydrate ratio 20:1 R. rosea decreased lifespan by about 10%. Flies fed Rhodiola preparation were physically more active, less sensitive to the redox-cycling compound menadione and had a longer time of heat coma onset compared with controls. Positive effects of Rhodiola rhizome on stress resistance and locomotor activity were highest at the ‘middle age’. The present data show that long-term food supplementation with R. rosea rhizome not only increases D. melanogaster lifespan, but also delays age-related decline of physical activity and increases stress resistance, what depends on protein-to-carbohydrate ratio of the diet.