MinK-Related Peptide 1
MinK-Related Peptide 1
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MinK 相关肽 1
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
Randy S. Wymore
中科院分区：
文献类型：
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作者：
Han;Jiying Wu;I. Potapova;R. Wymore;B. Holmes;J. Zuckerman;Z. Pan;Hong;W. Shi;R. Robinson;M. El‐Maghrabi;W. Benjamin;J. Dixon;D. Mckinnon;I. Cohen;Randy S. Wymore
摘要 —HCN 离子通道亚基家族是心脏电流 I f 以及神经系统电流 I h 和 I q 的基础。在本研究中，我们证明 minK 相关肽 1 (MiRP1) 是 HCN 家族的 β 亚基。因此，它增强了蛋白质和电流的表达，并加速了激活动力学。由于 MiRP1 还充当心脏延迟整流器 I Kr 的 β 亚基，因此这些结果表明该肽可能具有调节心脏起搏器活动基础的向内和向外通道的独特作用。本文全文可在 http://www.circresaha.org 上获取。
Abstract —The HCN family of ion channel subunits underlies the currents I f in heart and I h and I q in the nervous system. In the present study, we demonstrate that minK-related peptide 1 (MiRP1) is a β subunit for the HCN family. As such, it enhances protein and current expression as well as accelerating the kinetics of activation. Because MiRP1 also functions as a β subunit for the cardiac delayed rectifier I Kr, these results suggest that this peptide may have the unique role of regulating both the inward and outward channels that underlie cardiac pacemaker activity. The full text of this article is available at http://www.circresaha.org.