Helicobacter pylori Infection

Helicobacter pylori Infection
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幽门螺杆菌感染

DOI:
10.1056/nejmcp1001110
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发表时间:
2010-04-29
影响因子:
158.5
通讯作者:
McColl, Kenneth E. L.
McColl, Kenneth E. L.
中科院分区:
医学1区
文献类型:
--
作者:
McColl, Kenneth E. L.

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一位29岁男性,间歇性上腹部不适,没有体重减轻或消化道出血的迹象。他报告没有使用阿司匹林或非甾体类抗炎药(NSAID)。腹部检查显示上腹部压痛。幽门螺杆菌的血清学检测呈阳性,他接受了为期10天的三联疗法(奥美拉唑、阿莫西林和克拉霉素)。六周后,他又出现了同样的症状。应如何进一步评估和管理他的案件?
A 29-year-old man presents with intermittent epigastric discomfort, without weight loss or evidence of gastrointestinal bleeding. He reports no use of aspirin or nonsteroidal antiinflammatory drugs (NSAIDs). Abdominal examination reveals epigastric tenderness. A serologic test for Helicobacter pylori is positive, and he receives a 10-day course of triple therapy (omeprazole, amoxicillin, and clarithromycin). Six weeks later, he returns with the same symptoms. How should his case be further evaluated and managed?