Protein Adaptation to High-Pressure Environments
Protein Adaptation to High-Pressure Environments
复制标题
蛋白质对高压环境的适应
DOI：
10.4131/jshpreview.18.128
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
C. Kato
中科院分区：
文献类型：
--
作者：
C. Kato
对压力适应（嗜压）蛋白质的研究一直落后于对其他极端蛋白质的研究，但最近对深海生物蛋白质的表征大大加速了这一领域的研究。最近对深海来源的蛋白质进行的实验有助于我们了解蛋白质对高压的适应。这些研究还补充了以前的工作，即研究压力对“正常”、不适应蛋白质的活性和稳定性的影响。总之，这项研究得出的结论是，由于暴露的侧链和大的内部空腔的水合作用，体积变化驱动蛋白质在高压下展开。
Studies of pressure-adapted (piezophilic) protein have lagged behind the investigation of other extremophilic proteins, however the recent characterization of proteins from deep-sea organisms has substantially accelerated the field. Recent experiments on proteins from deep-sea sources have contributed to our understanding of protein adaptation to high pressure. These studies have also complemented previous work that had investigated the effect of pressure on the activity and stability of “normal”, unadapted proteins. Together this research has lead to the conclusion that volume changes due to the hydration effects of exposed side chains and large internal cavities drive protein unfolding under high pressure.