Retinal reattachment and ERG recovery after ophthalmic artery chemosurgery for advanced retinoblastoma in eyes with minimal baseline retinal function
Retinal reattachment and ERG recovery after ophthalmic artery chemosurgery for advanced retinoblastoma in eyes with minimal baseline retinal function
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DOI：
10.1136/bjophthalmol-2016-308591
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发表时间：
2017-05-01
影响因子：
4.1
通讯作者：
Brodie, Scott E.
中科院分区：
文献类型：
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作者：
Abdelhakim, Aliaa H.;Francis, Jasmine H.;Brodie, Scott E.
目的 报告治疗前视网膜功能极低的晚期视网膜母细胞瘤 (RB) 眼动脉化疗 (OAC) 后的视网膜功能结果。方法 对于 72 只晚期 RB 眼，其基线视网膜电图 (ERG) 与噪声（“熄灭”）或闪烁无法区分，ERG 振幅 = 25 μV 变化，无 RD 分辨率。结论 最小基线 ERG 并不排除显着恢复OAC 后的视网膜功能。 3 个月的 ERG 结果与后续随访的结果之间存在良好的相关性，表明 OAC 后 3 个月的 ERG 振幅可以预测长期视网膜功能，并且这种改善是持久的。对于出现 RD 的眼睛，RD 分辨率是必要的，但不足以显着 (>= 25 mu V) ERG 振幅增加。
Aim To report retinal function outcomes after ophthalmic artery chemosurgery (OAC) for advanced retinoblastoma (RB) in eyes with minimal pretreatment retinal function.Methods For 72 advanced RB eyes with baseline electroretinograms (ERGs) indistinguishable from noise ('extinguished') or flicker ERG amplitudes = 25 mu V change without RD resolution.Conclusions Minimal baseline ERGs do not preclude significant recovery of retinal function after OAC. Good correlation exists between ERG outcomes at 3 months and those at subsequent follow-ups, suggesting that ERG amplitudes at 3-month post-OAC can prognosticate longer term retinal function, and that improvement is durable. For eyes presenting with RD, RD resolution is necessary but not sufficient for significant (>= 25 mu V) increases in ERG amplitudes.