High-fidelity Computer Models for Prospective Treatment Planning of Radiofrequency Ablation with In Vitro Experimental Correlation
High-fidelity Computer Models for Prospective Treatment Planning of Radiofrequency Ablation with In Vitro Experimental Correlation
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DOI：
10.1016/j.jvir.2010.07.022
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发表时间：
2010-11-01
影响因子：
2.9
通讯作者：
Feng, Yusheng
中科院分区：
文献类型：
--
作者：
Fuentes, David;Cardan, Rex;Feng, Yusheng
目的评估体外灌注牛肝脏模型中射频消融过程产生的热损伤区域的计算机模拟预测的准确性，肝脏模型中的热剂量终点用于定量评估计算机预测，用于射频消融过程的前瞻性治疗计划。材料和方法模拟了三冷尖端电极的几何细节，电阻加热脉冲电压传递在高性能并行计算架构上使用有限元模型（FEM）进行四维模拟。一系列物理真实的血液灌注参数，3 -53 6 kg/sec/m(3)；采用Arrhenius损伤模型来预测热剂量，Dice相似系数（DSC）是计算预测结果与体外灌注牛肝模型RF过程中获得的t1加权对比增强图像之间比较的度量。在物理上有意义的灌注值范围内，16 3-33 1 kg/sec/m(3)，预测的热剂量在给药后2分钟内达到最大损伤体积，并且与从灌注肝脏模型获得的实验测量结果（DSC > 0 7）吻合良好。热剂量的计算机预测精度与体外灌注牛肝模型在物理真实灌注值范围内测量的消融病变具有良好的相关性
PURPOSE To evaluate the accuracy of computer simulation in predicting the thermal damage region produced by a radiofrequency (RF) ablation procedure in an in vitro perfused bovine liver model The thermal dose end point in the liver model is used to assess quantitatively computer prediction for use in prospective treatment planning of RE ablation proceduresMATERIALS AND METHODS Geometric details of the tri-cooled tip electrode were modeled The resistive heating of a pulsed voltage delivery was simulated in four dimensions using finite element models (FEM) implemented on high-performance parallel computing architectures A range of physically realistic blood perfusion parameters, 3 6-53 6 kg/sec/m(3), was considered in the computer model An Arrhenius damage model was used to predict the thermal dose Dice similarity coefficients (DSC) were the metric of comparison between computational predictions and T1-weighted contrast-enhanced images of the damage obtained from a RF procedure performed on an in vitro perfused bovine liver modelRESULTS For a perfusion parameter greater than 16 3 kg/sec/m(3), simulations predict the temporal evolution of the damaged volume is perfusion limited and will reach a maximum value Over a range of physically meaningful perfusion values, 16 3-33 1 kg/sec/m(3), the predicted thermal dose reaches the maximum damage volume within 2 minutes of the delivery and is in good agreement (DSC > 0 7) with experimental measurements obtained from the perfused liver modelCONCLUSIONS As measured by the computed volumetric DSC, computer prediction accuracy of the thermal dose shows good correlation with ablation lesions measured in vitro in perfused bovine liver models over a range of physically realistic perfusion values