The Sulfur Microbial Diet and Risk of Colorectal Cancer by Molecular Subtypes and Intratumoral Microbial Species in Adult Men.
The Sulfur Microbial Diet and Risk of Colorectal Cancer by Molecular Subtypes and Intratumoral Microbial Species in Adult Men.
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DOI：
10.14309/ctg.0000000000000338
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发表时间：
2021-08-01
影响因子：
3.6
通讯作者：
Chan AT
中科院分区：
文献类型：
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作者：
Sikavi DR;Nguyen LH;Haruki K;Ugai T;Ma W;Wang DD;Thompson KN;Yan Y;Branck T;Wilkinson JE;Akimoto N;Zhong R;Lau MC;Mima K;Kosumi K;Morikawa T;Rimm EB;Garrett WS;Izard J;Cao Y;Song M;Huttenhower C;Ogino S;Chan AT
我们最近描述了硫微生物饮食，这是一种与肠道硫代谢细菌增加和远端结直肠癌（CRC）发病率相关的摄入模式。我们评估了这种风险是否因 CRC 分子亚型或参与 CRC 发病机制的瘤内微生物（具核梭杆菌和双歧杆菌属）的存在而不同。我们在卫生专业人员随访研究（1986-2012）中进行了 Cox 比例风险模型，以按分子和微生物亚型检查含硫微生物饮食与整体和远端 CRC 发病率之间的关联。我们记录了 48,246 名男性中的 1,264 例 CRC 病例，其中约 40% 拥有可用的组织数据。在考虑了多重假设检验后，硫微生物饮食与结直肠癌发病率之间的关系并没有因亚型而异。然而，有人建议，对于 PTGS2 高 CRC，前列腺素合酶 2 (PTGS2) 状态与硫微生物饮食评分最高与最低三分位数的多变量调整风险比为 1.31（95% 置信区间：0.99–1.74，Ptrend = 0.07，Pheterogenity = 0.04）存在关联。硫微生物饮食与远端结直肠癌的关联似乎因瘤内双歧杆菌属的存在而不同。双歧杆菌阴性远端 CRC 的硫微生物饮食评分最高与最低三分位数的调整后风险比为 1.65（95% 置信区间：1.14-2.39，Ptrend = 0.01，Pheterogenity = 0.03）。我们观察到其他测试的分子标记没有明显的异质性。长期坚持硫微生物饮食可能与男性 PTGS2 高和双歧杆菌阴性远端结直肠癌相关。需要进行更多研究来进一步表征肠道微生物硫代谢和 CRC 的作用。
We recently described the sulfur microbial diet, a pattern of intake associated with increased gut sulfur-metabolizing bacteria and incidence of distal colorectal cancer (CRC). We assessed whether this risk differed by CRC molecular subtypes or presence of intratumoral microbes involved in CRC pathogenesis (Fusobacterium nucleatum and Bifidobacterium spp.). We performed Cox proportional hazards modeling to examine the association between the sulfur microbial diet and incidence of overall and distal CRC by molecular and microbial subtype in the Health Professionals Follow-Up Study (1986–2012). We documented 1,264 incident CRC cases among 48,246 men, approximately 40% of whom had available tissue data. After accounting for multiple hypothesis testing, the relationship between the sulfur microbial diet and CRC incidence did not differ by subtype. However, there was a suggestion of an association by prostaglandin synthase 2 (PTGS2) status with a multivariable adjusted hazard ratio for highest vs lowest tertile of sulfur microbial diet scores of 1.31 (95% confidence interval: 0.99–1.74, Ptrend = 0.07, Pheterogeneity = 0.04) for PTGS2-high CRC. The association of the sulfur microbial diet with distal CRC seemed to differ by the presence of intratumoral Bifidobacterium spp. with an adjusted hazard ratio for highest vs lowest tertile of sulfur microbial diet scores of 1.65 (95% confidence interval: 1.14–2.39, Ptrend = 0.01, Pheterogeneity = 0.03) for Bifidobacterium-negative distal CRC. We observed no apparent heterogeneity by other tested molecular markers. Greater long-term adherence to the sulfur microbial diet could be associated with PTGS2-high and Bifidobacterium-negative distal CRC in men. Additional studies are needed to further characterize the role of gut microbial sulfur metabolism and CRC.