Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
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DOI：
10.1007/s00439-012-1246-3
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发表时间：
2013-03
期刊：
影响因子：
5.3
通讯作者：
Edwards, Todd L.
中科院分区：
文献类型：
--
作者：
Edwards, Digna R. Velez;Naj, Adam C.;Monda, Keri;North, Kari E.;Neuhouser, Marian;Magvanjav, Oyunbileg;Kusimo, Ibukun;Vitolins, Mara Z.;Manson, JoAnn E.;O'Sullivan, Mary Jo;Rampersaud, Evadnie;Edwards, Todd L.
肥胖措施的全基因组关联研究已经确定了与单核苷酸多态性（snp）的关联。然而，尚未对基因-环境相互作用进行大规模评估。我们对来自妇女健康倡议SNP健康协会资源GWAS研究的绝经后非裔美国人和西班牙裔妇女的基因-环境（G×E）相互作用进行了搜索。对身体质量指数（BMI）和腰臀围比（WHR）进行单SNP线性回归，校正了多维尺度衍生的祖先和年龄轴，在种族分层的数据中，非洲裔美国人（N=8,203）有871,512个SNP，西班牙裔美国人（N=3,484）有786,776个SNP。在非裔美国人和西班牙裔美国人中进行了G×E相互作用项的meta分析，对所有snp进行了G×E相互作用测试，这些snp与娱乐性体育活动（小时/周）、饮食能量摄入（千卡/天）、酒精摄入量（分类）、吸烟年数和吸烟（曾经vs从未）有关。吸烟和rs10133840标记物（Q统计值P=0.70, β = - 0.01， P=3.81×10 - 7）是非洲裔美国人和西班牙裔美国人之间一致的G×E相互作用的最有力证据。在一个队列中，G×E相互作用的最有力证据是非洲裔美国人，WHR作为饮食能量摄入和rs9557704的结果（SNP×kcal =−0.04，P=2.17×10−7）。没有结果超过bonferroni校正的统计显著性阈值。
Genome-wide association studies of obesity measures have identified associations with single nucleotide polymorphisms (SNPs). However, no large-scale evaluation of gene-environment interactions has been performed. We conducted a search of gene-environment (G×E) interactions in post-menopausal African-American and Hispanic women from the Women’s Health Initiative SNP Health Association Resource GWAS study. Single SNP linear regression on body mass index (BMI) and waist-to-hip circumference ratio (WHR) adjusted for multidimensional-scaling-derived axes of ancestry and age was run in race-stratified data with 871,512 SNPs available from African-Americans (N=8,203) and 786,776 SNPs from Hispanics (N=3,484). Tests of G×E interaction at all SNPs for recreational physical activity (met-hrs/wk), dietary energy intake (kcal/day), alcohol intake (categorical), cigarette smoking years, and cigarette smoking (ever vs. never) were run in African-Americans and Hispanics adjusted for ancestry and age at interview, followed by meta-analysis of G×E interaction terms. The strongest evidence for concordant G×E interactions in African-Americans and Hispanics was for smoking and marker rs10133840 (Q statistic P=0.70, beta=−0.01, P=3.81×10−7) with BMI as the outcome. The strongest evidence for G×E interaction within a cohort was in African-Americans with WHR as outcome for dietary energy intake and rs9557704 (SNP×kcal =−0.04, P=2.17×10−7). No results exceeded the Bonferroni–corrected statistical significance threshold.
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影响因子：
120.7
作者：
Flegal, Katherine M.;Carroll, Margaret D.;Curtin, Lester R.
通讯作者：
Curtin, Lester R.
影响因子：
4.5
作者：
Hicks AA;Pramstaller PP;Johansson A;Vitart V;Rudan I;Ugocsai P;Aulchenko Y;Franklin CS;Liebisch G;Erdmann J;Jonasson I;Zorkoltseva IV;Pattaro C;Hayward C;Isaacs A;Hengstenberg C;Campbell S;Gnewuch C;Janssens AC;Kirichenko AV;König IR;Marroni F;Polasek O;Demirkan A;Kolcic I;Schwienbacher C;Igl W;Biloglav Z;Witteman JC;Pichler I;Zaboli G;Axenovich TI;Peters A;Schreiber S;Wichmann HE;Schunkert H;Hastie N;Oostra BA;Wild SH;Meitinger T;Gyllensten U;van Duijn CM;Wilson JF;Wright A;Schmitz G;Campbell H
通讯作者：
Campbell H
影响因子：
2.7
作者：
Abraham R;Moskvina V;Sims R;Hollingworth P;Morgan A;Georgieva L;Dowzell K;Cichon S;Hillmer AM;O'Donovan MC;Williams J;Owen MJ;Kirov G
通讯作者：
Kirov G
DOI：
10.1159/000264407
发表时间：
2010-01-01
期刊：
FRONTIERS IN EATING AND WEIGHT REGULATION
影响因子：
--
作者：
Hetherington, Marion M.;Cecil, Joanne E.
通讯作者：
Cecil, Joanne E.
DOI：
10.1016/j.bbalip.2005.08.006
发表时间：
2005-10-15
影响因子：
4.8
作者：
Hojjati, MR;Li, ZQ;Jiang, XC
通讯作者：
Jiang, XC