Vaso-occlusive retinopathy associated with antiphospholipid antibodies (lupus anticoagulant retinopathy).
Vaso-occlusive retinopathy associated with antiphospholipid antibodies (lupus anticoagulant retinopathy).
复制标题
与抗磷脂抗体相关的血管闭塞性视网膜病（狼疮抗凝性视网膜病）。
DOI：
10.1016/s0161-6420(89)32825-9
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发表时间：
1989
期刊：
影响因子：
13.7
通讯作者：
Kaplan,HJ
中科院分区：
文献类型：
--
作者：
Kleiner,RC;Najarian,LV;Schatten,S;Jabs,DA;Patz,A;Kaplan,HJ
作者观察了3例(6只眼)与狼疮抗凝剂及相关抗磷脂抗体抗心磷脂相关的血管阻塞性视网膜病变。这种疾病发生在没有可定义的自身免疫性疾病的患者中，如系统性红斑狼疮(SLE)，其特征是严重的双眼视网膜血管阻塞。视网膜内缺血和视网膜前新生血管导致的玻璃体出血造成严重的视力损失。实验室检测结果显示，2例患者部分凝血活酶时间(PTT)延长，所有患者均存在狼疮抗凝剂。全视网膜光凝治疗似乎稳定了新生血管。全身抗凝和免疫抑制治疗的作用尚不确定。眼科96：896-904,1989
The authors observed three cases (6 eyes) of vaso-occlusive retinopathy associated with the lupus anticoagulant and the related antiphospholipid antibody anticardiolipin. The disease occurred in patients who had no definable autoimmune disease such as systemic lupus erythematosus (SLE) and was characterized by severe bilateral retinal vascular occlusion. There was profound visual loss from intraretinal ischemia as well as vitreous hemorrhage from preretinal neovascularization. Results of laboratory testing showed a prolonged partial thromboplastin time (PTT) in two patients, and the presence of the lupus anticoagulant in all. Treatment with panretinal photocoagulation appeared to stabilize the neovascularization. The role of systemic anticoagulation and immunosuppressive therapy is uncertain. Ophthalmology 96:896-904,1989