Systematic investigation of preparing biocompatible, single, and small ZnS-capped CdSe quantum dots with amphiphilic polymers
Systematic investigation of preparing biocompatible, single, and small ZnS-capped CdSe quantum dots with amphiphilic polymers
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DOI：
10.1021/nn700450g
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发表时间：
2008-07-01
期刊：
影响因子：
17.1
通讯作者：
Chan, Warren C. W.
中科院分区：
文献类型：
--
作者：
Anderson, Robin E.;Chan, Warren C. W.
纳米颗粒在溶剂之间的成功转移对于许多应用来说是至关重要的。我们评估了两亲性聚合物组合物对三正辛基氧化膦/十六烷基胺稳定的半导体ZnS封端的CdSe和CdS封端的CdTexSe 1-x量子点（QD）的尺寸、转移效率和生物相容性的影响。我们还研究了各种蛋白质吸附到这些量子点的表面上，并研究了表面化学对非特异性蛋白质结合的影响。这些研究的结果将对量子点和其他生物和生物医学应用纳米粒子的设计产生影响。
The successful transfer of nanoparticles between solvents is critical for many applications. We evaluated the impact of amphiphilic polymer composition on the size, transfer efficiency, and biocompatibility of tri-n-octylphosphine oxide/hexadecylamine-stabilized semiconductor ZnS-capped CdSe and CdS-capped CdTexSe1-x quantum dots (QDs). We also investigated the adsorption of various proteins onto the surface of these QDs and studied the effect of surface chemistry on non-specific protein binding. The results from these studies will have implications in the design of QDs and other nanoparticles for biological and biomedical applications.