The role of PRKCH gene variants in coronary artery disease in a Chinese population
The role of PRKCH gene variants in coronary artery disease in a Chinese population
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DOI：
10.1007/s11033-011-0918-8
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发表时间：
2011-05
影响因子：
2.8
通讯作者：
Jun Zhu;Jianjun Yan;Zheng-Ping Kuai;Wei Gao;Jian-Jin Tang;En-Zhi Jia;Zhijian Yang;Liansheng Wang-Liansheng-Wan
中科院分区：
文献类型：
--
作者：
Jun Zhu;Jianjun Yan;Zheng-Ping Kuai;Wei Gao;Jian-Jin Tang;En-Zhi Jia;Zhijian Yang;Liansheng Wang-Liansheng-Wan
本研究旨在评估PRKCH基因变异(1425G/A和_15)对中国人群冠状动脉疾病(CAD)风险的影响。我们的研究人群包括470名冠心病患者和434名对照对象。冠心病组中这两个变异的等位基因频率显著高于对照组(1425G/A的P=0.001和_15的P=0.001)。在冠心病组中，1425G/A和_15等位基因携带者的低密度脂蛋白胆固醇水平高于纯合子G等位基因携带者(P=0.001和P=0.021)。在调整了年龄、性别、体重指数等因素的多元Logistic回归模型中，携带GA或AA基因的人群发生冠心病的风险显著增加(P=0.005和P=0.018)。总之，我们观察到在中国人群中，PRKCH基因的小等位基因(1425G/A和_15)与冠心病风险增加和低密度脂蛋白水平升高显著相关。
The aim of the present study was to assess the influences of PRKCH gene variants (1425G/A and _15) on the risk of coronary artery disease (CAD) in a Chinese population. Our study population consisted of 470 CAD patients and 434 control subjects. The alleles frequencies of the two variants were significantly higher among CAD patients than control subjects (P= 0.001 for 1425G/A andP= 0.001 for _15, respectively). In the CAD group, the A allele carriers of 1425G/A and _15 polymorphisms had higher low-density lipoprotein cholesterol (LDL-C) levels than homozygote G allele carriers (P= 0.001 andP= 0.021, respectively). In a multiple logistic regression model adjusted for age, sex, body mass index (BMI), etc., a markedly increased risk of developing CAD was found in subjects carrying GA or AA genotype (P= 0.005 andP= 0.018, respectively). In conclusion, we observed that there was a remarkable association of minor alleles (1425G/A and _15) in the PRKCH gene with an elevated risk of CAD and increased levels of LDL-C in this Chinese population.