Mathematical aspects of dose-response studies in carcinogenesis--the concept of thresholds.
Mathematical aspects of dose-response studies in carcinogenesis--the concept of thresholds.
复制标题
致癌作用剂量反应研究的数学方面——阈值的概念。
作者：
C. Brown
许多以前提出的致癌理论，其中涉及的致癌物质的暴露水平预期的肿瘤反应，进行了总结，并指出，这些理论假设存在没有阈值水平。修改的一击致癌模型，将纳入一个阈值，提出了沿着与概括的可变阈值的人口风险。本文讨论了从生物测定实验数据中判别阈值模型和非阈值模型的统计问题，并给出了一个实例。
Many of the previously proposed theories of carcinogenesis which relate the exposure level of a carcinogen to expected tumor response, are summarized and it is pointed out that these theories assume the existence of no threshold level. A modification of the one-hit carcinogenic model which would incorporate a threshold, is proposed along with a generalization to variable thresholds over the population at risk. The statistical problems of discriminating between threshold and non-threshold models from experimental bioassay data are discussed and an example is given.