Protective immunity against avian influenza induced by a fowlpox virus recombinant.
Protective immunity against avian influenza induced by a fowlpox virus recombinant.
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DOI：
10.1016/0264-410x(88)90101-6
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发表时间：
1988-12
期刊：
影响因子：
5.5
通讯作者：
Jill Taylor;R. Weinberg;Y. Kawaoka;R. G. Webster;Enzo Paoletti;Enzo Paoletti
中科院分区：
文献类型：
--
作者：
Jill Taylor;R. Weinberg;Y. Kawaoka;R. G. Webster;Enzo Paoletti;Enzo Paoletti
禽痘病毒是禽痘病毒属的原型病毒，其自然宿主范围仅限于禽类。因此，禽痘病毒提供了一个合适的候选物种特异性重组病毒载体的发展。本文报道了一种表达高毒禽流感病毒血凝素分子的禽痘病毒重组株的研制。在鸡和火鸡的重组免疫，保护提供了致命的挑战，无论是同源或异源流感病毒株。
Fowlpox virus, the prototypic virus of the genusAvipoxvirushas a natural host range limited to avian species. As such, fowlpox virus provides a suitable candidate for the development of a species-specific recombinant viral vector. This paper reports the development of a fowlpox virus recombinant expressing the haemagglutinin molecule from a highly virulent avian influenza virus. On immunization of chickens and turkeys with the recombinant, protection is afforded against a lethal challenge with either the homologous or a heterologous influenza virus strain.