A immunohistochemical study of the peripheral ameloblastoma
A immunohistochemical study of the peripheral ameloblastoma
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DOI：
10.1111/j.1601-0825.2006.01340.x
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发表时间：
2007-11-01
期刊：
影响因子：
3.8
通讯作者：
Toyosawa, S.
中科院分区：
文献类型：
--
作者：
Kishino, M.;Murakami, S.;Toyosawa, S.
目的外周成釉细胞瘤（PA）是发生在骨外区域的一种罕见的成釉细胞瘤。关于肿瘤的组织发生，考虑了两个主要的起源来源：牙源性上皮残余和牙龈上皮。在本研究中，我们检测了PA的细胞角蛋白（ck）和Ki-67标记指数（LI）的免疫组化谱，并讨论了PA的组织发生和生物学行为。材料与方法从我院登记的212例成釉细胞瘤的病理资料中检索8例PA。7例患者采用6种ck（7、8、13、14、18、19）和Ki-67单克隆抗体进行免疫组化染色。结果所有PA均表达CK13、ck14、ck19。CK18阳性6例，CK8阳性5例。这种染色模式与骨内成釉细胞瘤（IAs）相似。PAs组Ki-67 LI均值（1.91%）显著低于IAs组（4.82%）（P = 0.002）。结论我们认为PA来源于牙源性上皮残体而非牙龈上皮，肿瘤的Ki-67 LI是一个很好的预后指标。
Aim Peripheral ameloblastoma (PA) is a rare variant of ameloblastoma occurring in the extraosseous region. With regard to the histogenesis of the tumor, two major sources of origin are considered: odontogenic epithelial remnants and the gingival epithelium. In this study, we examined the immunohistochemical profiles of cytokeratins (CKs) and Ki-67 labeling index (LI) of PAs, and discuss the histogenesis and the biologic behavior of the PA.Materials and Methods Eight cases of PA were retrieved from the pathology files of 212 cases of ameloblastoma that had been registered at our hospital. Immunohistochemical staining was performed in seven cases using monoclonal antibodies of six CKs (7, 8, 13, 14, 18, and 19) and Ki-67.Results All cases of PA expressed CK13, 14, and 19. CK18 was positive staining in six cases, and CK8 in five cases. This staining pattern was similar to that in intraosseous ameloblastomas (IAs). The mean of Ki-67 LI of PAs (1.91%) was significantly lower than that of IAs (4.82%) (P = 0.002).Conclusion We consider that the PA originates from odontogenic epithelial remnants rather than from the gingival epithelium, and the Ki-67 LI of the tumor is a good prognostic indicator.