Disordered Cholinergic Neurotransmission and Dysautoregulation After Acute Cerebral Infarction
Disordered Cholinergic Neurotransmission and Dysautoregulation After Acute Cerebral Infarction
复制标题
急性脑梗塞后胆碱能神经传递紊乱和失调
作者：
E. Ott;J. Abraham;J. Meyer;A. Achari;A. N. Chee;N. Mathew
通过阻塞狒狒大脑中动脉（MCA）造成实验性局部脑梗塞，研究了移位的神经递质乙酰胆碱（ACh）在自动调节障碍中的可能作用。颈动脉注射133氙后，用γ照相机测量局部脑血流量（rCBF）。用间羟胺或血管紧张素输注测试自动调节，并且自动调节指数（A.I.）被计算。在非梗死和梗死半球的脑组织中测定乙酰胆碱酯酶（AChE）。脑动静脉（A-V）胆碱酯酶（ChE）的差异也进行了测量。区域性自动调节障碍被发现在梗死的灰质和相关的乙酰胆碱酯酶水平增加，在同一区的皮质和基底神经节。自动调节障碍的发病时间与脑胆碱酯酶摄取增加相关。静脉注射胆碱能神经递质阻滞剂东莨菪碱，恢复缺血区的自动调节。自我调节似乎是一种肌源性反射，受神经源性和代谢机制的影响。
The possible role of displaced neurotransmitter acetylcholine (ACh) in dysautoregulation was examined after experimental regional cerebral infarction was produced by occluding the middle cerebral artery (MCA) in baboons. Regional cerebral blood flow (rCBF) was measured after intracarotid injection of 133Xenon using the gamma camera. Autoregulation was tested with metaraminol or angiotensin infusion and the autoregulation index (A.I.) was calculated. Acetylcholinesterase (AChE) was measured in brain tissue of noninfarcted and infarcted hemispheres. Cerebral arteriovenous (A-V) differences for cholinesterase (ChE) were also measured. Regional dysautoregulation was found in infarcted gray matter and correlated with increased AChE levels in the same zones of cortex and basal ganglia. The time course of onset of dysautoregulation correlated with increased ChE uptake by the brain. Intravenous infusion of the cholinergic neurotransmitter blocker, scopolamine, restored autoregulation to the ischemic zones. Autoregulation appears to be a myogenic reflex, influenced by neurogenic and metabolic mechanisms.