Perioperative Serum Carcinoembryonic Antigen Ratio Is a Prognostic Indicator in Patients With Stage II Colorectal Cancer.
Perioperative Serum Carcinoembryonic Antigen Ratio Is a Prognostic Indicator in Patients With Stage II Colorectal Cancer.
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DOI：
10.3393/ac.2018.34.1.4
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发表时间：
2018-03
影响因子：
3.1
通讯作者：
Kim KH
中科院分区：
文献类型：
--
作者：
Woo J;Kim J;Park I;Cho H;Gwak G;Yang KH;Bae BN;Kim KH
本研究的目的是评估围手术期癌胚抗原（CEA）的比例是否可以作为一个决定因素，辅助治疗后，根治性手术在II期结直肠癌。收集了2010年至2013年期间接受根治性手术的119例II期结直肠癌患者的数据。围手术期CEA比值定义为术后/术前血清CEA水平，并根据围手术期CEA比值将患者分为高比值（≥0.5）和低比值（<0.5）。计算总生存率，并分析其预后意义。围手术期高CEA组和低CEA组的总生存率分别为68.2%和86.8%（P = 0.033）。在术前CEA水平正常（<5 ng/mL）的患者中，围手术期CEA高比值组的生存率低于围手术期CEA低比值组（71.7% vs. 100.0%，P = 0.007）。在术前CEA水平较高（≥5 ng/mL）的患者中，围手术期CEA比值较高组的生存率低于围手术期CEA比值较低组（33.3% vs. 75.0%，P = 0.036）。在多变量分析中，围手术期CEA比值（P = 0.046）、年龄（P = 0.034）和静脉侵犯（P = 0.015）是影响生存率的独立预后因素。围手术期CEA比值是II期结直肠癌的预后指标。术前血清CEA水平正常的患者，如果其围手术期CEA比值高于0.5，也可考虑进行辅助治疗。
The aim of this study was to evaluate whether the perioperative carcinoembryonic antigen (CEA) ratio could be used as a determinant for adjuvant therapy after curative surgery in stage II colorectal cancer. Data for 119 patients with stage II colorectal cancer who underwent radical surgery between 2010 and 2013 were collected. The perioperative CEA ratio was defined as the postoperative/preoperative serum CEA level, and the patients were grouped according to their perioperative CEA ratios: high ratio (≥0.5) and low ratio (<0.5). Overall survival rates were calculated, and their prognostic significances were analyzed. The overall survival rates of the high and the low perioperative CEA groups were 68.2% and 86.8%, respectively (P = 0.033). In patients with normal preoperative CEA levels (<5 ng/mL), the high perioperative CEA ratio group showed a worse survival rate than the low perioperative CEA ratio group (71.7% vs. 100.0%, P = 0.007). In patients with high preoperative CEA levels (≥5 ng/mL), the high perioperative CEA ratio group showed a worse survival rate than the low perioperative CEA ratio group (33.3% vs. 75.0%, P = 0.036). In the multivariate analysis, perioperative CEA ratio (P = 0.046), age (P = 0.034), and venous invasion (P = 0.015) were independent prognostic factors for survival. The perioperative CEA ratio is a prognostic indicator for stage II colorectal cancer. Patients with normal preoperative serum CEA levels might also be considered for adjuvant therapy if their perioperative CEA ratios are higher than 0.5.