Polycystic Ovarian Syndrome Management Options
Polycystic Ovarian Syndrome Management Options
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DOI：
10.1016/j.ogc.2012.10.001
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发表时间：
2012-12-01
影响因子：
3.2
通讯作者：
Propst, Anthony M.
中科院分区：
文献类型：
--
作者：
Bates, G. Wright, Jr.;Propst, Anthony M.
多囊卵巢综合征（PCOS）是一种雄激素过多和卵巢功能障碍的疾病。多毛症和游离睾酮水平升高是雄激素过多最一致的迹象。月经不规律、不频繁或无月经和不孕症是排卵功能障碍的症状。肥胖也是这种综合征的一个特征，并导致相关的代谢异常。生活方式的改变应该是第一个治疗，并有效地减少体征和症状。与PCOS相关的排卵性不孕症在大多数情况下可以通过口服（克罗米芬或来曲唑）或注射（促性腺激素）药物来克服。外科干预是保留的情况下抵抗医疗管理。
Polycystic ovarian syndrome (PCOS) is a disorder of androgen excess and ovarian dysfunction. Hirsutism and elevated free testosterone levels are the most consistent signs of the androgen excess. Irregular, infrequent, or absent menses and infertility are symptoms of ovulatory dysfunction. Obesity is also a feature of this syndrome and contributes to associated metabolic abnormalities. Lifestyle modification should be the first treatment and is effective in reducing the signs and symptoms. The ovulatory infertility associated with PCOS can be overcome in most cases with oral (clomiphene citrate or letrozole) or injectable (gonadotropins) agents. Surgical intervention is reserved for cases resistant to medical management.