A new method to evaluate the effects of shear on the skin
A new method to evaluate the effects of shear on the skin
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DOI：
10.1111/wrr.12368
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发表时间：
2015-11-01
影响因子：
2.9
通讯作者：
Bouvy, Nicole D.
中科院分区：
文献类型：
--
作者：
de Wert, Luuk A.;Bader, Dan L.;Bouvy, Nicole D.
目前，压疮的预防策略主要集中在压力再分布。很少有人注意到减少剪切力的有害影响，因为很少有人知道剪切力的病理生理方面。即使在今天，也没有方法来测量剪切力对皮肤的影响。因此，本研究的目的是通过分析健康受试者皮肤上测量的非侵入性生物标志物和反应性充血参数来研究对剪切力的反应。开发了物理模型，以在皮肤上产生压力和剪切的组合或单独的压力。包括10名健康男性参与者，并在前臂掌侧施加压力（3.9 kPa）和压力和剪切的组合载荷（2.4 kPa+14.5 N），持续15分钟和30分钟。Sebutape样品用于非侵入性地收集IL-1和总蛋白（TP）。反应性充血参数来自激光多普勒流量计。与所有其他测试条件相比，在压力和剪切组合负荷30分钟后IL-1/TP比率增加6.2 +/- 2.5显著更高（p
Currently, pressure ulcer preventive strategies focus mainly on pressure redistribution. Little attention is paid to reduce the harmful effects of shear-force, because little is known about pathophysiological aspects of shear-force. Even today, no method to measure the effects of shear-force on the skin is available. Therefore, the aim of this study was to investigate the response to shear-forces in terms of analyzing a noninvasive biomarker and reactive hyperemic parameter measured at the skin of healthy participants. A physical model was developed to produce a combination of pressure and shear or pressure alone on the skin. Ten healthy male participants were included and pressure (3.9 kPa) and a combined loading of pressure and shear (2.4 kPa+14.5 N) was applied at the volar aspect of the forearms for 15 and 30 minutes. A Sebutape sample was used to collect IL-1 and total protein (TP) noninvasively. The reactive hyperemic parameter was derived from a laser Doppler flowmeter. The increase in IL-1/TP-ratio after a combined loading of pressure and shear for 30 minutes of 6.2 +/- 2.5 was significantly higher compared with all other test conditions (p