A novel Tungsten-based fiducial marker for multi-modal brain imaging
A novel Tungsten-based fiducial marker for multi-modal brain imaging
复制标题
一种用于多模式脑成像的新型钨基基准标记
DOI：
10.1016/j.jneumeth.2019.04.014
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发表时间：
2019
影响因子：
3
通讯作者：
Hayashi Takuya
中科院分区：
文献类型：
--
作者：
Ose Takayuki;Autio Joonas A.;Ohno Masahiro;Nishigori Kantaro;Tanki Nobuyoshi;Igesaka Ami;Mori Tomoko;Doi Hisashi;Wada Yasuhiro;Nakajima Iwao;Watabe Hiroshi;Hayashi Takuya
背景多模态脑图像配准是神经科学中精确绘制脑结构和功能的前提。图像配准通常使用自动化软件进行;然而，当图像在模态、对比度、均匀性和分辨率方面不同时，其准确性降低。这种限制可以通过使用外部参考点来克服;然而，在多模态imaging中的高对比度剂以前没有reported.New methodsHere，我们提出了一种新的多模态基准标记，包含钨溶液，并提供高对比度的磁共振成像（MRI），计算机断层扫描（CT），和正电子发射断层扫描（PET）。通过评估以下模式中的图像对比度的主要来源，研究了该多模式标记物的基本特征：结果钨溶液具有较低的T1和T2弛豫率和较高的溶解度，在高密度浓度下，T1和T2加权MR和CT图像显示出较高的对比度（约3.0 g/mL），而其他传统的解决方案并没有表现出足够的对比度，无论是在CT或MRI。与现有的方法比较使用这种基于钨的多模态标记允许更准确的登记比一个软件的方法在幻影和动物实验。这种方法的应用证明了准确的皮质表面映射的神经递质功能（多巴胺转运蛋白，DAT）使用PET和MRI，并提供了一个神经生物学相关的皮质分布与以前的文献组织学为基础的DAT immunoreactivity.ConclusionsThe钨为基础的多模态基准标记是非放射性的，易于处理，并有助于精确注册不同形式的脑成像。
BackgroundMulti-modal brain image registration is a prerequisite for accurate mapping of brain structure and function in neuroscience. Image registration is commonly performed using automated software; however, its accuracy decreases when images differ in modality, contrast, uniformity, and resolution. This limitation could be overcome by using an external reference point; however, high-contrast agents in multi-modal imaging have not been previously reported.New methodsHere, we propose a novel multi-modal fiducial marker that contains Tungsten solution and provides high contrast in magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET). The basic characteristics of this multi-modal marker were investigated by assessing major sources of image contrast in the following modalities: density and T1-, T2-relaxivity in comparison with conventional contrast agents.ResultsTungsten solution had lower T1- and T2-relaxivity and high solubility, and showed high contrast in T1- and T2-weighted MR and CT images at a high-density concentration (˜3.0 g/mL), whereas other conventional solutions did not show sufficient contrast in either CT or MRI.Comparison with existing methodsThe use of this Tungsten-based multi-modal marker allowed more accurate registration than a software-only method in phantom and animal experiments. Application of this method demonstrated accurate cortical surface mapping of neurotransmitter function (dopamine transporter, DAT) using PET and MRI, and provided a neurobiologically relevant cortical distribution consistent with previous literature on histology-based DAT immunoreactivity.ConclusionsThe Tungsten-based multi-modal fiducial marker is non-radioactive, easy to handle, and aids precise registration across different modalities of brain imaging.