Time-varying amygdala response to emotional faces in generalized social phobia
Time-varying amygdala response to emotional faces in generalized social phobia
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DOI：
10.1016/j.biopsych.2006.09.017
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发表时间：
2007-09-01
影响因子：
10.6
通讯作者：
Reiss, Jeffrey P.
中科院分区：
文献类型：
--
作者：
Campbell, Darren W.;Sareen, Jitender;Reiss, Jeffrey P.
背景资料：社交恐惧症（SP）患者对情绪化面孔的行为和神经反应发生了改变，并被假设在抑制情绪相关的杏仁核反应方面存在缺陷。我们测试了这种杏仁核赤字的个人样本中的SP的情绪面孔。方法：我们使用功能性磁共振成像（fMRI）检查的神经基板的情绪面孔处理在14个广义SP（gSP）和14个健康的比较（HC）的参与者。分析集中在杏仁核的时间动态，前额叶皮层（PFC），和梭状面区（FFA）的跨块的中性，恐惧，蔑视，愤怒，和快乐的面孔在gSP与HC participator.Results：杏仁核的反应与gSP的参与者发生后比HC参与者的恐惧，愤怒，和快乐的面孔。平行PFC反应发现快乐和恐惧的脸。在FFA.Conclusions的时间反应模式没有组间差异：这一发现可能反映了与gSP个体之间的非典型定向反应的神经相关性。通常报道的SP缺陷的习惯可能反映了神经区域与情绪的自我评价，而不是杏仁核。这项研究强调了考虑时变调制的重要性，当检查情绪相关的处理与gSP的个人。
Background: Individuals with social phobia (SP) have altered behavioral and neural responses to emotional faces and are hypothesized to have deficits in inhibiting emotion-related amygdala responses. We tested for such amygdala deficits to emotional faces in a sample of individuals with SP.Method: We used functional magnetic resonance imaging (fMRI) to examine the neural substrates of emotional face processing in 14 generalized SP (gSP) and 14 healthy comparison (HC) participants. Analyses focused on the temporal dynamics of the amygdala, prefrontal cortex (PFC), and fusiform face area (FFA) across blocks of neutral, fear, contempt, anger, and happy faces in gSP versus HC participants.Results: Amygdala responses in participants with gSP occurred later than the HC participants to fear, angry, and happy faces. Parallel PFC responses were found for happy and fear faces. There were no group differences in temporal response patterns in the FFA.Conclusions: This finding might reflect a neural correlate of atypical orienting responses among individuals with gSP. Commonly reported SP deficits in habituation might reflect neural regions associated with emotional self-evaluations rather than the amygdala. This study highlights the importance of considering time-varying modulation when examining emotion-related processing in individuals with gSP.