Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil
Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil
复制标题
DOI：
10.11606/s1518-8787.2020054002643
复制
发表时间：
2020-01-01
期刊：
影响因子：
--
通讯作者：
Werneck, Guilherme Loureiro
中科院分区：
文献类型：
--
作者：
Amorim Filho, Luiz;Szwarcwald, Célia Landmann;Werneck, Guilherme Loureiro
目的：评估巴西巴西里约热内卢州献血者中SARS-CoV-2抗体的血清阳性率。方法：收集2020年4月14日至27日2857名献血者的数据。本研究报告了SARS-CoV-2抗体的粗流行率、该州的人口加权流行率以及根据检测敏感性和特异性调整的流行率。采用Logistic回归模型建立SARS-CoV-2流行的相关因素。为了进行分析，我们考虑了收集时间和地点、社会人口特征和居住地。结果：未经调整的SARS-Cov-2阳性检测比例为4.0% (95%CI 3.3 ~ 4.7%)，加权患病率为3.8% （95%CI 3.1 ~ 4.5%）。在调整了检测敏感性和特异性后，我们发现较低的估计值：非加权患病率为3.6% (95%CI 2.7-4.4%)，加权患病率为3.3% （95%CI 2.6-4.1%）。收集期是与粗患病率最显著相关的变量：收集期越晚，患病率越高。在社会人口学特征方面，献血者年龄越小，患病率越高，受教育程度越低，SARS-Cov-2抗体检测阳性的几率越高。我们在加权患病率方面发现了类似的结果。结论：我们的发现符合一些基本前提：随着时间的推移呈上升趋势，该州的流行曲线仍呈上升趋势；最年轻的人群（比年龄较大的人群更频繁地走动）和受教育程度较低的人群（在遵循社交距离建议方面遇到更多困难）的患病率更高。尽管研究存在局限性，但我们可以推断，巴西里约热内卢远未达到针对SARS-CoV-2的群体免疫所需水平。
OBJECTIVE: To estimate the seroprevalence of antibodies to SARS-CoV-2 among blood donors in the state of Rio de Janeiro, Brazil.METHODS: Data were collected on 2,857 blood donors from April 14 to 27, 2020. This study reports crude prevalence of antibodies to SARS-CoV-2, population weighted prevalence for the state, and prevalence adjusted for test sensitivity and specificity. Logistic regression models were used to establish the correlates of SARS-CoV-2 prevalence. For the analysis, we considered collection period and site, sociodemographic characteristics, and place of residence.RESULTS: The proportion of positive tests for SARS-Cov-2, without any adjustment, was 4.0% (95%CI 3.3-4.7%), and the weighted prevalence was 3.8% (95%CI 3.1-4.5%). We found lower estimates after adjusting for test sensitivity and specificity: 3.6% (95%CI 2.7-4.4%) for the non-weighted prevalence, and 3.3% (95%CI 2.6-4.1%) for the weighted prevalence. Collection period was the variable most significantly associated with crude prevalence: the later the period, the higher the prevalence. Regarding sociodemographic characteristics, the younger the blood donor, the higher the prevalence, and the lower the education level, the higher the odds of testing positive for SARS-Cov-2 antibody. We found similar results for weighted prevalence.CONCLUSIONS: Our findings comply with some basic premises: the increasing trend over time, as the epidemic curve in the state is still on the rise; and the higher prevalence among both the youngest, for moving around more than older age groups, and the less educated, for encountering more difficulties in following social distancing recommendations. Despite the study limitations, we may infer that Rio de Janeiro is far from reaching the required levels of herd immunity against SARS-CoV-2.