Continuous 3D Particles Manipulation Based on Cooling Thermal Convection
Continuous 3D Particles Manipulation Based on Cooling Thermal Convection
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DOI：
10.1016/j.snb.2022.131511
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发表时间：
2022-01
期刊：
影响因子：
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通讯作者：
Yigang Shen;Yapeng Yuan;Tao Tang;Nobutoshi Ota;N. Tanaka;Y. Hosokawa;Yaxiaer Yalikun;Yo Tanaka
中科院分区：
文献类型：
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作者：
Yigang Shen;Yapeng Yuan;Tao Tang;Nobutoshi Ota;N. Tanaka;Y. Hosokawa;Yaxiaer Yalikun;Yo Tanaka
能够灵巧地操纵颗粒/细胞的技术对于生物检测、分析化学和材料合成应用具有重要意义。尽管有很多方法可以实现静态条件下的3D操纵，但缺乏足够的连续流下的3D操纵策略。我们开发了一种集成微系统，带有基于热对流的冷却系统，以实现连续流中的 3D 操作。理论模型和实验表明，随着微加热器温度的升高，颗粒的运动方向从y轴转移到z轴。根据该原理，在 y 轴和 z 轴上操纵聚焦流和单个粒子。此外，还制作了不同z轴上的五个出口来演示颗粒分选的应用。这种新颖的策略为垂直颗粒操纵提供了新的方向，并有利于揭示微尺度的传热，这可以为生成下一个用于颗粒/细胞分选的集成微流体系统铺平道路。
Techniques that can dexterously manipulate particles/cells are significant for biological detection, analytical chemistry, and material synthesis applications. Although there are many methods to realize the 3D manipulation in a static condition, there is a lack of sufficient 3D manipulating strategies in a continuous flow. We develop an integrated microsystem with a cooling system based on thermal convection to realize 3D manipulation in continuous flow. Theoretical modeling and experiments demonstrate that with increasing the temperature of a microheater, the moving direction of particles transfers from the y-axis to the z-axis. Based on the principle, focusing flow and single particles are manipulated in the y-axis and z-axis. Besides, five outlets in different z-axis are fabricated to demonstrate the application of particle sorting. This novel strategy offers a new direction for particle manipulation vertically and benefits to reveal the heat transfer in micro-scale, which can pave a path for generating the next integrated microfluidic system for particles/cells sorting.