Low-frequency facial hemodynamic oscillations distinguish migraineurs from non-headache controls.
Low-frequency facial hemodynamic oscillations distinguish migraineurs from non-headache controls.
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DOI：
10.1177/2515816319888216
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发表时间：
2019-01-01
影响因子：
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通讯作者：
Brennan KC
中科院分区：
文献类型：
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作者：
Cortez MM;Theriot JJ;Rea NA;Gowen FE;Brennan KC
表面成像是一种有前途的，非侵入性的方法来评估局部脑血管疾病，如偏头痛灌注。我们使用光学成像检查面部血容量在基线和对氨吸入（一种有害刺激）的反应的差异，以及心血管自主神经功能的标准化测量，在健康的非头痛对照组（n = 43）和发作间期偏头痛受试者（n = 22）中。与健康对照组相比，偏头痛患者的静息面部皮肤振荡（FCO）频率有显著差异。吸入氨后，健康对照组静息FCO频率显著增加，而偏头痛组的这种反应并不显著。标准化的自主神经反射参数在研究组之间没有显著差异，面部皮肤活动与标准化的心血管自主神经反射参数不相关，表明可能存在不同的调节。这种方法来评估颅面血流动力学功能似乎表现出不同的机制，从以前可用的技术，并代表了一个有前途的新的生理生物标志物的颅面血管功能的研究偏头痛和潜在的其他颅血管疾病。
Surface imaging is a promising, noninvasive approach to assess regional perfusion in craniovascular disorders such as migraine. We used optical imaging to examine differences in facial blood volume at baseline and in response to ammonia inhalation (a noxious stimulus), as well as standardized measures of cardiovascular autonomic function, in healthy, non-headache controls (n = 43) and in interictal migraine subjects (n = 22). Resting facial cutaneous oscillation (FCO) frequency was significantly different in migraine compared to healthy controls. Following ammonia inhalation, healthy controls showed a significant increase in resting FCO frequency, whereas this response was not significant in the migraine group. Standardized autonomic reflex parameters did not differ significantly between study groups, and facial cutaneous activity did not correlate with standardized cardiovascular autonomic reflex parameters, suggesting potentially different regulation. This approach to the assessment of craniofacial hemodynamic function appears to exhibit differing mechanisms from previously available techniques, and represents a promising new physiological biomarker for the study of craniofacial vascular function in migraine and potentially other craniovascular disorders.