Joint aging and chondrocyte cell death.
Joint aging and chondrocyte cell death.
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DOI：
10.2217/ijr.10.3
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
D'Lima DD
中科院分区：
文献类型：
--
作者：
Grogan SP;D'Lima DD
关节软骨细胞外基质和细胞功能随着年龄的增长而变化，被认为是骨关节炎发生和发展的最重要因素。关节疾病的多方面性质表明，细胞死亡的贡献可能是骨关节炎早期和晚期的重要因素。因此，细胞死亡的药理学抑制可能在疾病的任何阶段都具有临床价值。在这篇文章中，我们将讨论软骨老化的各种变化之间的密切联系，改变条件如何影响软骨细胞死亡，以及防止细胞丢失以延缓骨关节炎进展和保持组织稳态的影响。
Articular cartilage extracellular matrix and cell function change with age and are considered to be the most important factors in the development and progression of osteoarthritis. The multifaceted nature of joint disease indicates that the contribution of cell death can be an important factor at early and late stages of osteoarthritis. Therefore, the pharmacologic inhibition of cell death is likely to be clinically valuable at any stage of the disease. In this article, we will discuss the close association between diverse changes in cartilage aging, how altered conditions influence chondrocyte death, and the implications of preventing cell loss to retard osteoarthritis progression and preserve tissue homeostasis.