Ultrasonic Enhanced Continuous Crystallization: Induction Time and Process Control
Ultrasonic Enhanced Continuous Crystallization: Induction Time and Process Control
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DOI：
10.1021/acs.iecr.3c02950
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发表时间：
2023-11
期刊：
影响因子：
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通讯作者：
Qiankun Zhao;Lixia Yang;Chaoqun Yao;Guang-mei Chen
中科院分区：
文献类型：
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作者：
Qiankun Zhao;Lixia Yang;Chaoqun Yao;Guang-mei Chen
设计了一种用于乙酰水杨酸连续反溶剂结晶的超声辅助管式结晶装置。COMSOL模拟和实验表征均表明，所设计的声结晶器具有较高的能量效率和良好的温度控制。研究了超声功率、超声作用时间、过饱和度、超声激励方式等因素对结晶过程的影响。由于流体混合的加强和空化气泡作为异相成核位点的引入，结晶显著增强。晶化诱导时间缩短到几百毫秒。在0.46 s内结晶效率可高达80%。晶体的平均粒径范围为8.2 ~ 40.1 μm，跨距值小于1。同时，脉冲激励方法可以在保持声致振荡优点的同时，进一步降低能量消耗。所有这些结果表明本结晶装置的性能远优于常规结晶器，验证了超声促进的有效性。结果还提供了洞察超声结晶的最佳操作条件。
An ultrasound-assisted tube crystallization device was designed for the continuous antisolvent crystallization of acetylsalicylic acid. Both the COMSOL simulation and experimental characterization showed that the designed acoustic crystallizer exhibited high energy efficiency and excellent temperature control. The effects of ultrasonic power, ultrasonic action time, supersaturation degree, and ultrasonic excitation method on the crystallization process were investigated. Due to the intensification of fluid mixing and the introduction of cavitation bubbles as the heterogeneous nucleation sites, the crystallization was significantly enhanced. The induction time of the crystallization was shortened to several hundred milliseconds. The crystallization efficiency could be as high as 80% achieved within 0.46 s. The average particle size of the crystals ranged from 8.2 to 40.1 μm, with a span value of less than 1. Meanwhile, the pulse excitation method can further reduce energy consumption while maintaining the advantages of sonocrystallization. All of these results indicate a far better performance of the present crystallization device than conventional crystallizers, validating the effectiveness of ultrasound promotion. The results also provide insights into optimal operating conditions for ultrasonic crystallization.