Reaction-diffusion model of hair-bundle morphogenesis
Reaction-diffusion model of hair-bundle morphogenesis
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DOI：
10.1073/pnas.1417420111
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发表时间：
2014-10-28
影响因子：
11.1
通讯作者：
Hudspeth, A. J.
中科院分区：
文献类型：
--
作者：
Jacobo, Adrian;Hudspeth, A. J.
毛束是毛细胞的顶端特化，由几排有规则组织的立体纤毛和一根肌纤毛组成，对耳内的机械传导至关重要。其精确的组织结构使发束能够将机械刺激转化为电信号；改变耳束形态的突变常常导致耳聋。然而，对参与形态发生过程的蛋白质以及这些分子之间的相互作用如何产生束的结构知之甚少。我们提出了一个基于简单反应-扩散机制的数学模型，可以再现头发束的形状和组织。这一模型表明，细胞边界和肌纤毛作为信号中心，决定了束的形状。两种蛋白质的相互作用形成六角形图灵模式，形成因子浓度的周期性调节，通过局部激活和长期抑制反应维持，为立体纤毛的位置设定了蓝图。最后，我们使用这个模型来预测系统的不同变化如何影响头发束的形状和组织。
The hair bundle, an apical specialization of the hair cell composed of several rows of regularly organized stereocilia and a kinocilium, is essential for mechanotransduction in the ear. Its precise organization allows the hair bundle to convert mechanical stimuli to electrical signals; mutations that alter the bundle's morphology often cause deafness. However, little is known about the proteins involved in the process of morphogenesis and how the structure of the bundle arises through interactions between these molecules. We present a mathematical model based on simple reaction-diffusion mechanisms that can reproduce the shape and organization of the hair bundle. This model suggests that the boundary of the cell and the kinocilium act as signaling centers that establish the bundle's shape. The interaction of two proteins forms a hexagonal Turing patterna periodic modulation of the concentrations of the morphogens, sustained by local activation and long-range inhibition of the reactants that sets a blueprint for the location of the stereocilia. Finally we use this model to predict how different alterations to the system might impact the shape and organization of the hair bundle.