Impact of Antidepressant Continuation After Acute Positive or Partial Treatment Response for Bipolar Depression: A Blinded, Randomized Study
Impact of Antidepressant Continuation After Acute Positive or Partial Treatment Response for Bipolar Depression: A Blinded, Randomized Study
复制标题
DOI：
10.4088/jcp.08m04191
复制
发表时间：
2009-04-01
影响因子：
5.3
通讯作者：
Suppes, Trisha
中科院分区：
文献类型：
--
作者：
Altshuler, Lori L.;Post, Robert M.;Suppes, Trisha
目的：为了评估双相情感障碍的长期结果，受试者接受急性治疗后，前瞻性地遵循双相depression.Method：83个DSM-IV双相抑郁症的门诊患者谁是1996年3月和2002年11月之间入组，并在10周的急性双盲抗抑郁药治疗试验同意参加为期1年的双盲继续他们的药物治疗。在急性抗抑郁药治疗试验中，受试者接受情绪稳定剂加3种随机分配的抗抑郁药中的1种治疗。61例受试者获得了急性阳性抗抑郁反应（抑郁症状量表[IDS]改善50%或双相情感障碍临床总体印象量表[CGI-BP]改善2分），22例受试者在10周急性试验结束时仅获得了急性部分改善。在盲继续阶段后立即进行急性试验，受试者继续使用相同的药物，并每月评定高达I年使用IDS，CGI-BP，和青年躁狂症评级scale.Results：在研究终点，42（69%）的61个急性阳性反应者保持阳性反应和32（53%）达到缓解。与急性阳性应答者相比，22例急性部分应答者中有6例（27%）在研究终点达到了阳性治疗应答（p
Objective: To assess long-term outcome in bipolar disorder, subjects were prospectively followed after receiving acute treatment for bipolar depression.Method: Eighty-three outpatients with DSM-IV bipolar depression who were enrolled between March 1996 and November 2002 and were treated in a 10-week acute double-blind antidepressant treatment trial agreed to participate in a 1-year double-blind continuation of their medication. In the acute antidepressant treatment trial, subjects were treated with a mood stabilizer plus 1 of 3 randomly assigned antidepressants. Sixty-one subjects had attained an acute positive antidepressant response (50% improvement on the Inventory for Depressive Symptomatology [IDS] or 2-point improvement on the Clinical Global Impression for Bipolar Disorder [CGI-BP]) and 22 subjects achieved only acute partial improvement at the end of the 10-week acute trial. In the blinded continuation phase immediately following the acute trial, subjects continued on the same medications and were rated monthly for up to I year using the IDS, CGI-BP, and the Young Mania Rating scale.Results: At study endpoint, 42 (69%) of the 61 acute positive responders maintained positive response and 32 (53%) achieved remission. Compared to the acute positive responders, 6 (27%) of the 22 acute partial responders had achieved positive treatment response at study endpoint (p