Continuous hydrophoretic separation and sizing of microparticles using slanted obstacles in a microchannel
Continuous hydrophoretic separation and sizing of microparticles using slanted obstacles in a microchannel
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DOI：
10.1039/b701227f
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发表时间：
2007-01-01
期刊：
影响因子：
6.1
通讯作者：
Park, Je-Kyun
中科院分区：
文献类型：
--
作者：
Choi, Sungyoung;Park, Je-Kyun
我们报道了一种微流控分离和测量微粒尺寸的方法，该方法利用微结构诱导的压力场影响下悬浮颗粒的运动。通过利用微通道中的倾斜障碍物，我们可以产生横向压力梯度，使得微粒可以沿着由梯度引起的横向流动偏转和排列。使用这样的运动的颗粒，我们完全分离聚苯乙烯微珠与9和12毫米直径。此外，我们区分聚苯乙烯微珠的直径差异相似的7.3%。此外，我们测量了10.4毫米的珠子的直径与高变异系数，并与传统的激光衍射方法的结果进行了比较。作为微通道中的微流体控制元件的倾斜障碍物类似于电、磁、光或声对应物，因为它们的功能是产生场梯度。由于我们的方法是基于内在的压力场，我们可以消除需要外部势场诱导粒子的运动。因此，我们的疏水方法将为集成微流体设备内的无功耗和生物相容性颗粒控制提供新的机会。
We report a microfluidic separation and sizing method of microparticles with hydrophoresis - the movement of suspended particles under the influence of a microstructure- induced pressure field. By exploiting slanted obstacles in a microchannel, we can generate a lateral pressure gradient so that microparticles can be deflected and arranged along the lateral flows induced by the gradient. Using such movements of particles, we completely separated polystyrene microbeads with 9 and 12 mm diameters. Also, we discriminated polystyrene microbeads with diameter differences of similar to 7.3%. Additionally, we measured the diameter of 10.4 mm beads with high coefficient of variation and compared the result with a conventional laser diffraction method. The slanted obstacle as a microfluidic control element in a microchannel is analogous to the electric, magnetic, optical, or acoustic counterparts in that their function is to generate a field gradient. Since our method is based on intrinsic pressure fields, we could eliminate the need for external potential fields to induce the movement of particles. Therefore, our hydrophoretic method will offer a new opportunity for power-free and biocompatible particle control within integrated microfluidic devices.