RADIATION AND HOST FACTORS IN HUMAN THYROID-TUMORS FOLLOWING THYMUS IRRADIATION
RADIATION AND HOST FACTORS IN HUMAN THYROID-TUMORS FOLLOWING THYMUS IRRADIATION
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DOI：
10.1097/00004032-198004000-00001
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发表时间：
1980-01-01
期刊：
影响因子：
2.2
通讯作者：
HEMPELMANN, LH
中科院分区：
文献类型：
--
作者：
SHORE, RE;WOODARD, ED;HEMPELMANN, LH
本文进一步分析了1971年美国纽约州罗切斯特市胸腺辐照人群的甲状腺肿瘤数据，以研究放射生物学和宿主因素。这项分析是基于大约2650名受辐射者和4800名兄弟姐妹的对照，他们接受了5年或更长时间的随访。放疗组甲状腺癌24例，甲状腺腺瘤52例，对照组无甲状腺癌，腺瘤6例。总体风险估计为3.8甲状腺癌/106 PY（人年）-rad和4.5甲状腺腺瘤/106 PY-rad。甲状腺癌的剂量-反应数据（甲状腺剂量范围为5至1000rad）显示线性和剂量平方分量，但甲状腺腺瘤没有明显的剂量平方分量。在较低的总剂量（< 400rad）下，剂量分割降低了甲状腺癌反应，但在甲状腺腺瘤中没有发现类似的分割效应。肿瘤的时间模式表明了过量肿瘤产生的延长平台期，而不是波浪形的时间模式。没有证据表明甲状腺辐射剂量与甲状腺癌潜伏期成反比关系。女性和犹太受试者患放射性甲状腺癌的风险高于他们各自的同行。比较了辐射效应的加性模型和乘性模型的性别差异；两个模型都不能很好地拟合数据。由于甲状腺癌的数量相对较少，因此强调结论的试探性。
Thyroid tumor data from the 1971 survey of the Rochester, New York, USA, thymus-irradiated population are further analyzed to study radiobiological and host factors. The analyses were based on about 2650 irradiated subjects and 4800 sibling controls who had 5 yr or more of follow-up. There were 24 thyroid cancers and 52 thyroid adenomas in the irradiated group and no thyroid cancers and 6 adenomas among the controls. The overall risk estimates were 3.8 thyroid cancers/106 PY(person-years)-rad and 4.5 thyroid adenomas/106 PY-rad. The dose-response data (thyroid dose range of 5 to > 1000 rad) for thyroid cancer indicate a linear and a dose-squared component, but no dose-squared component is evident for thyroid adenomas. At lower total doses (< 400 rad) there was a suggestion that dose fractionation diminished the thyroid cancer response, but a similar fractionation effect was not found for thyroid adenomas. The temporal pattern of tumors suggested an extended plateau of excess tumor production, rather than a wavelike temporal pattern. There was no evidence for an inverse relationship between thyroid radiation dose and thyroid cancer latency. Female and Jewish subjects had a higher risk of radiation-induced thyroid cancer than did their respective counterparts. The additive and multiplicative models of radiation effects were compared with respect to sex differences; neither model provided a superior fit to the data. The tentative nature of the conclusions is stressed because of the relatively small number of thyroid cancers.