Primary cicatricial alopecia: Histopathologic findings do not distinguish clinical variants
Primary cicatricial alopecia: Histopathologic findings do not distinguish clinical variants
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DOI：
10.1016/j.jaad.2004.07.069
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发表时间：
2005-04-01
影响因子：
13.8
通讯作者：
Price, VH
中科院分区：
文献类型：
--
作者：
Mirmirani, P;Willey, A;Price, VH
背景：原发性瘢痕性脱发包括一组以毛囊永久性破坏为特征的疾病。不同的临床特征和术语的差异导致了难以确定一致的临床病理学相关性。目的：我们寻求6种临床上不同的原发性瘢痕性脱发的临床病理学相关性：扁平苔藓，额部纤维化脱发，假性脱发（Brocq），中央离心性脱发，脱发性毛囊炎和簇状毛囊炎。方法：我们对临床典型的原发性瘢痕性脱发进行了前瞻性盲法组织病理学评价。活检标本取自早期受影响的头皮病变和配对的样本，从临床上未受影响的地区在同一patient.Results：淋巴细胞和嗜中性粒细胞组很容易区分组织学。然而，在这两组临床上不同的原发性瘢痕性脱发不能区分与当前的组织病理学techniques.Conclusion：一个描述性的，标准化的组织病理学报告的毛囊结构，类型，位置和程度的炎症浸润，和存在或不存在的皮脂腺，可能是最有价值的指导治疗原发性瘢痕性脱发患者。
Background: Primary cicatricial alopecias encompass a group of disorders characterized by permanent destruction of the hair follicle. The varied clinical features and differences in terminology have led to difficulties in defining consistent clinicopathologic correlation.Objective: We sought clinicopathologic correlation of 6 clinically distinct primary cicatricial alopecias: lichen planopilaris, frontal fibrosing alopecia, pseudopelade (Brocq), central centrifugal alopecia, folliculitis decalvans, and tufted folliculitis.Methods: We conducted prospective and blinded histopathologic evaluation of clinically typical primary cicatricial alopecias. Biopsy specimens were taken from early affected scalp lesions and paired with samples from clinically unaffected areas in the same patient.Results: The lymphocytic and neutrophilic groups were readily distinguished histologically. However, within the two groups clinically distinct primary cicatricial alopecias could not be distinguished with current histopathologic techniques.Conclusion: A descriptive, standardized histopathologic reporting of follicular architecture, type, location, and extent of the inflammatory infiltrate, and presence or absence of sebaceous glands, may be of greatest value in guiding the treatment of patients with primary cicatricial alopecias.