The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex.
The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex.
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DOI：
10.1038/ng.2771
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发表时间：
2013-11
期刊：
影响因子：
30.8
通讯作者：
Chinnaiyan, Arul M.
中科院分区：
文献类型：
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作者：
Prensner, John R.;Iyer, Matthew K.;Sahu, Anirban;Asangani, Irfan A.;Cao, Qi;Patel, Lalit;Vergara, Ismael A.;Davicioni, Elai;Erho, Nicholas;Ghadessi, Mercedeh;Jenkins, Robert B.;Triche, Timothy J.;Malik, Rohit;Bedenis, Rachel;McGregor, Natalie;Ma, Teng;Chen, Wei;Han, Sumin;Jing, Xiaojun;Cao, Xuhong;Wang, Xiaoju;Chandler, Benjamin;Yan, Wei;Siddiqui, Javed;Kunju, Lakshmi P.;Dhanasekaran, Saravana M.;Pienta, Kenneth J.;Feng, Felix Y.;Chinnaiyan, Arul M.
前列腺癌在大多数人中仍然是惰性的，但在少数人中表现为侵袭性。这种临床异质性的分子基础仍然不完全清楚。在这里，我们描述了一种称为SChLAP1(与前列腺癌-1相关的第二染色体位点；也称为LINC00913)的长非编码RNA，它在前列腺癌的一个子集中过表达。SChLAP1水平独立地预测不良预后，包括转移和前列腺癌特异性死亡率。体内外功能丧失和功能丧失实验表明，SChLAP1对癌细胞的侵袭和转移至关重要。从机制上讲，SChLAP1拮抗SWI/SNF染色质修饰复合体的全基因组定位和调节功能。这些结果表明，SChLAP1至少部分地通过拮抗SWI/SNF复合体的肿瘤抑制功能而促进了致命性癌症的发展。
Prostate cancers remain indolent in the majority of individuals but behave aggressively in a minority,. The molecular basis for this clinical heterogeneity remains incompletely understood,,. Here we characterize a long noncoding RNA termedSChLAP1(second chromosome locus associated with prostate-1; also calledLINC00913) that is overexpressed in a subset of prostate cancers.SChLAP1levels independently predict poor outcomes, including metastasis and prostate cancer–specific mortality.In vitroandin vivogain-of-function and loss-of-function experiments indicate thatSChLAP1is critical for cancer cell invasiveness and metastasis. Mechanistically,SChLAP1antagonizes the genome-wide localization and regulatory functions of the SWI/SNF chromatin-modifying complex. These results suggest thatSChLAP1contributes to the development of lethal cancer at least in part by antagonizing the tumor-suppressive functions of the SWI/SNF complex.
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将转录因子识别为单一的同源物2作为前列腺癌中潜在的生物标志物和免疫疗法靶标。
DOI：
10.1158/1078-0432.ccr-09-0911
发表时间：
2009-09-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Arredouani MS;Lu B;Bhasin M;Eljanne M;Yue W;Mosquera JM;Bubley GJ;Li V;Rubin MA;Libermann TA;Sanda MG
通讯作者：
Sanda MG
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
45.3
作者：
Cooperberg, MR;Moul, JW;Carroll, PR
通讯作者：
Carroll, PR
影响因子：
15.9
作者：
Glinsky, GV;Glinskii, AB;Gerald, WL
通讯作者：
Gerald, WL
影响因子：
64.8
作者：
Berger, Michael F.;Lawrence, Michael S.;Demichelis, Francesca;Drier, Yotam;Cibulskis, Kristian;Sivachenko, Andrey Y.;Sboner, Andrea;Esgueva, Raquel;Pflueger, Dorothee;Sougnez, Carrie;Onofrio, Robert;Carter, Scott L.;Park, Kyung;Habegger, Lukas;Ambrogio, Lauren;Fennell, Timothy;Parkin, Melissa;Saksena, Gordon;Voet, Douglas;Ramos, Alex H.;Pugh, Trevor J.;Wilkinson, Jane;Fisher, Sheila;Winckler, Wendy;Mahan, Scott;Ardlie, Kristin;Baldwin, Jennifer;Simons, Jonathan W.;Kitabayashi, Naoki;MacDonald, Theresa Y.;Kantoff, Philip W.;Chin, Lynda;Gabriel, Stacey B.;Gerstein, Mark B.;Golub, Todd R.;Meyerson, Matthew;Tewari, Ashutosh;Lander, Eric S.;Getz, Gad;Rubin, Mark A.;Garraway, Levi A.
通讯作者：
Garraway, Levi A.