Variant BDNF (VAl66Met) impact on brain structure and function
Variant BDNF (VAl66Met) impact on brain structure and function
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DOI：
10.3758/cabn.6.1.79
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发表时间：
2006-03-01
影响因子：
2.9
通讯作者：
Lee, FS
中科院分区：
文献类型：
--
作者：
Bath, KG;Lee, FS
神经营养因子，如脑源性神经营养因子（BDNF），是一个独特的多肽生长因子家族，影响发育中的神经系统神经元的分化和存活。在成人中，BDNF在调节大脑突触可塑性和连通性方面很重要。最近，人类BDNF基因中常见的单核苷酸多态性，导致原域（Val66Met）的缬氨酸到蛋氨酸的替代，已被证明会导致记忆障碍和对神经精神疾病的易感性。了解这种自然发生的多态性如何影响成人的行为、解剖和认知，是将神经营养因子系统的遗传改变与人类可定义的生物学结果联系起来的重要的第一步。我们回顾了最近与BDNF多态性相关的文献。在体外和转基因动物研究的背景下，bdnf在成人大脑神经元功能中的核心作用。
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are a unique family of polypeptide growth factors that influence differentiation and survival of neurons in the developing nervous system. In adults, BDNF is important in regulating synaptic plasticity and connectivity in the brain. Recently, a common single-nucleotide polymorphism in the human BDNF gene, resulting in a valine to methionine substitution in the prodomain (Val66Met), has been shown to lead to memory impairment and susceptibility to neuropsychiatric disorders. An understanding of how this naturally occurring polymorphism affects behavior, anatomy, and cognition in adults is an important first step in linking genetic alterations in the neurotrophin system to definable biological outcomes in humans. We review the recent literature linking this BDNF polymorphism. to cognitive impairment in the context of in vitro and transgenic animal studies that have established BDNFs central role in neuronal functioning in the adult brain.