Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials

Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials
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DOI:
10.1136/bmj.d4002
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发表时间:
2011-07-22
影响因子:
105.7
通讯作者:
Higgins, Julian P. T.
Higgins, Julian P. T.
中科院分区:
医学1区
文献类型:
--
作者:
Sterne, Jonathan A. C.;Sutton, Alex J.;Higgins, Julian P. T.

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漏斗图和漏斗图不对称性检验已被广泛用于检查荟萃分析结果的偏倚。漏斗图不对称不应等同于发表偏倚,因为它有许多其他可能的原因。本文介绍了如何解释漏斗图的不对称性,推荐适当的测试,并解释了荟萃分析模型的选择的含义。
Funnel plots, and tests for funnel plot asymmetry, have been widely used to examine bias in the results of meta-analyses. Funnel plot asymmetry should not be equated with publication bias, because it has a number of other possible causes. This article describes how to interpret funnel plot asymmetry, recommends appropriate tests, and explains the implications for choice of meta-analysis model.