Ultradian variation in serum phosphate concentration in patients on haemodialysis.
Ultradian variation in serum phosphate concentration in patients on haemodialysis.
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血液透析患者血清磷酸盐浓度的超日变化。
DOI：
10.1093/oxfordjournals.ndt.a090854
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
L. Fog
中科院分区：
文献类型：
--
作者：
T. Ring;A. K. Sanden;H. Hansen;P. Halkier;C. Nielsen;L. Fog
为了研究在计划透析前一天血清磷酸盐浓度的变化，我们对9名维持血液透析的患者在24小时内进行了24-37次定时测量。观察期间血清磷酸盐浓度升高0.239 +/- 0.022,P < 0.01)。令人惊讶的是，9名患者中有6名出现了9个具有统计学和临床意义的最低点，减少了0.21 +/- 0.04 mmol/l，而测定内标准差约为0.05 mmol/l。其中五个最低点出现在11.40-14.50，平均为12.59，三个最低点出现在19.00-21.30，平均为20.00。我们发现血钙浓度没有相应的变化。这些发现表明，血清磷酸盐浓度并不总是反映磷平衡或摄入量。
To study how much the serum phosphate concentration could vary on the day before scheduled dialysis we obtained 24-37 timed measurements during 24 h in nine patients on maintenance haemodialysis. During the observation there was an increase in serum phosphate concentration of 0.239 +/- 0.022, P < 0.01). Surprisingly six of the nine patients exhibited nine statistically and clinically significant nadirs with decrements of 0.21 +/- 0.04 mmol/l against an intra-assay standard deviation of about 0.05 mmol/l. Five of the nadirs occurred at 11.40-14.50, mean 12.59, and three at 19.00-21.30, mean 20.00. We found no coinciding changes in the serum calcium concentration. These findings indicate that serum phosphate concentrations do not always reflect phosphorus balance or intake.