New Efficient Synthesis of 2-Substituted 5,6,7,8-Tetrahydro-benzothieno[2,3-d]pyrimidin-4(3H)-ones
New Efficient Synthesis of 2-Substituted 5,6,7,8-Tetrahydro-benzothieno[2,3-d]pyrimidin-4(3H)-ones
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DOI：
10.1055/s-2003-44358
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发表时间：
2003-12
期刊：
影响因子：
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通讯作者：
M. Ding;Shang-Jun Yang;Jinge G. Zhu
中科院分区：
文献类型：
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作者：
M. Ding;Shang-Jun Yang;Jinge G. Zhu
The carbodiimides 4, obtained from aza-Wittig reactions of iminophosphorane 3 with aromatic isocyanates, reacted with secondary amines to give 2-dialkylamino-5,6,7,8-tetrahydro-benzothieno[2,3-d]pyrimidin-4(3H)-ones 6 in presence of catalytic EtO - Na + . Reactions of 4 with phenols or ROH in presence of catalytic K 2 CO 3 or RO - Na + gave 2-aryl(alkyl)oxy-5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidin-4(3H)-ones 6 in satisfactory yields. The effects of the nucleophiles on cyclization have been investigated.
