IL-25 contributes to development of chronic contact dermatitis in C57BL/6 mice, but not BALB/c mice
IL-25 contributes to development of chronic contact dermatitis in C57BL/6 mice, but not BALB/c mice
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IL-25 导致 C57BL/6 小鼠慢性接触性皮炎的发生，但与 BALB/c 小鼠无关
DOI：
10.1016/j.bbrc.2022.08.077
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发表时间：
2022
影响因子：
3.1
通讯作者：
Nakae Susumu
中科院分区：
文献类型：
--
作者：
Shimura Eri;Suto Hajime;Numata Takafumi;Yamaguchi Sachiko;Harada Kazutoshi;Okumura Ko;Sudo Katsuko;Ikutani Masashi;Nakae Susumu
特应性皮炎（AD）是一种以2型免疫反应为特征的慢性炎症性皮肤病。白细胞介素-25（IL-25）主要由上皮细胞产生。它可以激活Th 2细胞产生2型细胞因子，如IL-4、IL-5和IL-13，有助于宿主防御线虫。然而，IL-25的过度/不适当产生被认为与2型尼古丁相关的过敏性疾病如哮喘的发展有关。另一方面，IL-25对AD发病机制的贡献仍然知之甚少。在本研究中，我们发现IL 25 mRNA的表达在恶唑酮诱导的慢性接触性超敏反应（CHS），这是一个人类AD的小鼠模型的小鼠皮肤中显着增加。此外，尽管IL-25对于半抗原特异性T细胞产生IL-4并不是必需的，但与野生型小鼠相比，在C57 BL/6背景下，IL-25缺陷（IL-25 −/−）小鼠中恶唑酮诱导的慢性CHS的发生显著减少，而在BALB/c背景下则没有。因此，IL-25对慢性CHS的发展至关重要，尽管这部分取决于小鼠的遗传背景。
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by type 2 immune responses. Interleukin-25 (IL-25) is produced predominantly by epithelial cells. It can activate Th2 cells to produce type 2 cytokines such as IL-4, IL-5 and IL-13, contributing to host defense against nematodes. However, excessive/inappropriate production of IL-25 is considered to be involved in development of type 2 cytokine-associated allergic disorders such as asthma. On the other hand, the contribution of IL-25 to the pathogenesis of AD remains poorly understood. In the present study, we found that expression ofIl25 mRNA was significantly increased in the skin of mice during oxazolone-induced chronic contact hypersensitivity (CHS), which is a mouse model of human AD. In addition, development of oxazolone-induced chronic CHS was significantly reduced in IL-25-deficient (Il25−/−) mice compared with wild-type mice on the C57BL/6, but not BALB/c, background, although IL-25 was not essential for IL-4 production by hapten-specific T cells. Therefore, IL-25 is crucial for development of chronic CHS, although that is partly dependent on the genetic background of the mice.