Identification of novel exons 3' to the human SNRPN gene.
Identification of novel exons 3' to the human SNRPN gene.
复制标题
鉴定人类 SNRPN 基因的新外显子 3。
DOI：
10.1006/geno.1996.4571
复制
发表时间：
1997
期刊：
影响因子：
4.4
通讯作者：
Bernhard Horsthemke
中科院分区：
文献类型：
--
作者：
K. Buiting;B. Dittrich;Sabine U. Endele;Bernhard Horsthemke
The gene for the small nuclear ribonucleoprotein N (SNRPN) maps to human chromosome 15 and has 10 exons. Using cDNA cloning, direct cDNA selection, and exon-connection reverse transcriptase (RT)-PCR, we have identified three novel 3' exons of SNRPN, which have no protein coding potential. Like the other SNRPN exons, the novel exons are expressed from the paternal allele only. In contrast to several cDNA clones and RT-PCR products, however, the 3.4-kb transcript detected by Northern blot hybridization with a probe for the novel exons does not contain SNRPN. It is possible that the steady-state RNA observed in fetal tissues and in adult testis, ovary, brain, and muscle is initiated at an as yet unidentified transcription start site downstream of SNRPN or is generated by endonucleolytic cleavage of a precursor transcript, as has been shown for another imprinted gene, the insulin-like growth factor II gene.
影响因子：
3.5
作者：
Sun, YM;Nicholls, RD;Palmer, CG
通讯作者：
Palmer, CG
编码小核核糖核蛋白相关蛋白 N 的基因在神经元中高水平表达。
DOI：
--
发表时间：
1992
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Schmauss,C;Brines,ML;Lerner,MR
通讯作者：
Lerner,MR
普瑞德-威利综合征区域一个新的父系表达基因的鉴定。
影响因子：
3.5
作者：
Wevrick,R;Kerns,JA;Francke,U
通讯作者：
Francke,U