Prognostic value of thoracic FDG PET imaging after treatment for non-small cell lung cancer
Prognostic value of thoracic FDG PET imaging after treatment for non-small cell lung cancer
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DOI：
10.2214/ajr.174.3.1740769
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发表时间：
2000-03-01
影响因子：
5
通讯作者：
Herndon, J
中科院分区：
文献类型：
--
作者：
Patz, EF;Connolly, J;Herndon, J
OBJECTIVE.我们确定了F-18-氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）对治疗过的肺癌患者的预后价值。我们检查了非小细胞肺癌一线治疗后接受FDG PET的患者。FDG PET结果与生存率相关，以确定FDG PET结果是否可预测预后。在初始治疗后，113例非小细胞肺癌患者接受了FDG PET检查。100例患者的FDG PET结果为阳性，中位生存期为12个月（95%置信区间，9.2-15.4）。13名患者的FDG PET结果为阴性，其中11名（85%）患者在中位随访34个月时仍然存活。FDG PET阳性和阴性患者的生存率差异具有统计学意义（p = 0.002）。FDG PET具有预后价值，并与接受治疗的肺癌患者的生存率密切相关。FDG PET结果阳性患者的预后明显差于阴性患者。此外，FDG PET可能有助于指导治疗。
OBJECTIVE. We determined the prognostic value of F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) for patients with treated lung cancer.MATERIALS AND METHODS. We examined patients who underwent FDG PET after first-line treatment for non-small cell lung cancer. FDG PET results were correlated with survival rates to determine whether FDG PET findings were predictive of outcomes.RESULTS. After initial therapy, 113 patients with non-small cell lung cancer underwent FDG PET. One hundred patients had positive FDG PET results and a median survival of 12 months (95% confidence interval, 9.2-15.4). Thirteen patients had negative FDG PET results, and 11 (85%) of these patients are still livings at a median follow-up of 34 months. The difference in survival for patients with positive and negative FDG PET results was statistically significant (p = 0.002).CONCLUSION. FDG PET has prognostic value and strongly correlates with survival rates of patients with treated lung cancer. Patients with positive FDG PET results have a significantly worse prognosis than patients with negative results. Additionally, FDG PET may be helpful in guiding therapeutic treatments.