Impact of unfounded vaccine safety concerns on the nationwide measles-rubella immunization campaign, Georgia, 2008
Impact of unfounded vaccine safety concerns on the nationwide measles-rubella immunization campaign, Georgia, 2008
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DOI：
10.1016/j.vaccine.2010.07.043
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发表时间：
2010-09-07
期刊：
影响因子：
5.5
通讯作者：
Martin, R.
中科院分区：
文献类型：
--
作者：
Khetsuriani, N.;Imnadze, P.;Martin, R.
媒体报道不良事件后对疫苗安全的担忧导致2008年格鲁吉亚麻疹-风疹补充免疫运动覆盖率低（50.3%）。对与该运动相关的不良事件的回顾确定了432例报告（49.3万名疫苗接种者中< 0.1%），其中包括338例晕厥（78.2%）。没有人员死亡。对79例被提供者认为严重且有临床细节的病例进行了因果关系评估。在13例（16.5%）病例中发现可能由疫苗引起的情况（过敏和局部反应、血小板减少症）。伴有晕厥或焦虑发作的37例（46.8%）；其中36例（97.3%）最初误诊为过敏性休克/过敏反应/“疫苗后反应”。合并症29例（36.7%）。对安全的担忧是毫无根据的，媒体报道和医生在识别晕厥/焦虑发作方面的困难夸大了这些担忧。为确保实现世界卫生组织欧洲区域消除麻疹和风疹的目标，迫切需要采取风险沟通战略，以解决已知的疫苗安全问题。Elsevier Ltd.出版。
Vaccine safety fears following media reports of adverse events led to low (50.3%) coverage in a supplementary measles-rubella immunization campaign in Georgia in 2008. Review of adverse events associated with the campaign identified 432 reports (< 0.1% of similar to 493,000 vaccinees) including 338 (78.2%) cases of syncope. There were no deaths. Causality assessment was performed for 79 cases perceived by providers as severe and with clinical details available. Conditions likely caused by the vaccine were identified in 13 (16.5%) cases (allergic and local reactions, thrombocytopenia). Thirty-seven (46.8%) cases had symptoms consistent with syncope or anxiety attack; 36 (97.3%) of them were initially misdiagnosed as anaphylactic shock/allergies/"postvaccinal reactions". Twenty-nine (36.7%) cases had coincidental illnesses. Safety fears were unfounded and exaggerated by media reports and providers' difficulties in recognizing syncope/anxiety attacks. Risk communication strategies to address perceived vaccine safety concerns are urgently needed to ensure that the goal of measles and rubella elimination in the European Region of the World Health Organization is met. Published by Elsevier Ltd.